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Pulmonary alveolar macrophages (PAMs) obtained by bronchopulmonary lavage from 6 normal non-smoking volunteers were incubated with [3H]-benzo[alpha]pyrene to ascertain the normal metabolism and conjugation of polycyclic aromatic hydrocarbons. Through the use of a crude glucuronidase preparation, both glucuronic acid and sulfate conjugates were examined. Phenols and quinones were identified by high-pressure liquid chromatography as the principal free metabolites formed during 1 h incubation with benzanthracene induced PAMs. In addition, phenols and quinones were major substrates utilized by these cells for conjugation during the incubation period. The ranges of benzo[alpha]pyrene metabolites produced by PAMs from non-smokers were compiled and the variation in production as well as detoxification of proximate carcinogenic benzo[alpha]pyrene metabolites are presented.
M V Marshall, and
T L McLemore, and
R R Martin, and
W T Jenkins, and
D R Snodgrass, and
M A Corson, and
M S Arnott, and
N P Wray, and
A C Griffin
March 1978,
Laboratory investigation; a journal of technical methods and pathology,
M V Marshall, and
T L McLemore, and
R R Martin, and
W T Jenkins, and
D R Snodgrass, and
M A Corson, and
M S Arnott, and
N P Wray, and
A C Griffin
April 1978,
Nature,
M V Marshall, and
T L McLemore, and
R R Martin, and
W T Jenkins, and
D R Snodgrass, and
M A Corson, and
M S Arnott, and
N P Wray, and
A C Griffin
May 1975,
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, praventive Medizin,
M V Marshall, and
T L McLemore, and
R R Martin, and
W T Jenkins, and
D R Snodgrass, and
M A Corson, and
M S Arnott, and
N P Wray, and
A C Griffin
July 1991,
Carcinogenesis,
M V Marshall, and
T L McLemore, and
R R Martin, and
W T Jenkins, and
D R Snodgrass, and
M A Corson, and
M S Arnott, and
N P Wray, and
A C Griffin
January 1985,
Carcinogenesis; a comprehensive survey,
M V Marshall, and
T L McLemore, and
R R Martin, and
W T Jenkins, and
D R Snodgrass, and
M A Corson, and
M S Arnott, and
N P Wray, and
A C Griffin
January 1982,
Voprosy onkologii,
M V Marshall, and
T L McLemore, and
R R Martin, and
W T Jenkins, and
D R Snodgrass, and
M A Corson, and
M S Arnott, and
N P Wray, and
A C Griffin
December 1979,
Chemico-biological interactions,
M V Marshall, and
T L McLemore, and
R R Martin, and
W T Jenkins, and
D R Snodgrass, and
M A Corson, and
M S Arnott, and
N P Wray, and
A C Griffin
June 1978,
Laboratory investigation; a journal of technical methods and pathology,
M V Marshall, and
T L McLemore, and
R R Martin, and
W T Jenkins, and
D R Snodgrass, and
M A Corson, and
M S Arnott, and
N P Wray, and
A C Griffin
August 1983,
Biochemical pharmacology,
M V Marshall, and
T L McLemore, and
R R Martin, and
W T Jenkins, and
D R Snodgrass, and
M A Corson, and
M S Arnott, and
N P Wray, and
A C Griffin
July 1979,
Cancer letters,
