Biomaterial Database

[Characteristics of fucidin biosynthesis by a Fusidium coccineum 257 A strain]. 1977

G A Penzikova, and N E Sepanova, and M M Levitov

The physiological features of Fusidium coccineum, strain 257 A, an organism producing fusidin were studied. It was found that increased concentrations of the carbon sources in the medium stimulated production of fusidin, while an increase in the content of various forms of nitrogen differently affected the level of the antibiotic viosynthesis: high concentrations of the amino acid-peptide form of nitrogen of corn-steep liquor decreased, while the protein form of nitrogen was associated with consumption of the significant part of carbon in the medium for formation of the fungus mycelium. Therefore, the concentration of the easily mobilizing forms of nitrogen may be considered as a regulator of the growth process of F. coccineum 257 A and production of fusidin by it.

UI	MeSH Term	Description	Entries
D009584	Nitrogen	An element with the atomic symbol N, atomic number 7, and atomic weight [14.00643; 14.00728]. Nitrogen exists as a diatomic gas and makes up about 78% of the earth's atmosphere by volume. It is a constituent of proteins and nucleic acids and found in all living cells.
D003470	Culture Media	Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.	Media, Culture
D003904	Mitosporic Fungi	A large and heterogenous group of fungi whose common characteristic is the absence of a sexual state. Many of the pathogenic fungi in humans belong to this group.	Deuteromycetes,Deuteromycota,Fungi imperfecti,Fungi, Mitosporic,Hyphomycetes,Deuteromycete,Deuteromycotas,Fungi imperfectus,Fungus, Mitosporic,Hyphomycete,Mitosporic Fungus,imperfectus, Fungi
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005672	Fusidic Acid	An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.	Fucithalmic,Fusidate Sodium,Fusidic Acid, Sodium Salt,Fusidin,Silver Fusidate,Sodium Fusidate,Stanicide,Acid, Fusidic,Fusidate, Silver,Fusidate, Sodium,Sodium, Fusidate
D050260	Carbohydrate Metabolism	Cellular processes in biosynthesis (anabolism) and degradation (catabolism) of CARBOHYDRATES.	Metabolism, Carbohydrate