BIOMAT Database Logo BIOMAT Database Logo

Pyrrolizidine alkaloid analogues. Preparation of semisynthetic esters of retronecine. 1977

W M Hoskins, and D H Crout

UI MeSH Term Description Entries
D008722 Methods A series of steps taken in order to conduct research. Techniques,Methodological Studies,Methodological Study,Procedures,Studies, Methodological,Study, Methodological,Method,Procedure,Technique
D011763 Pyrrolizidine Alkaloids A group of ALKALOIDS, characterized by a nitrogen-containing necine, occurring mainly in plants of the BORAGINACEAE; COMPOSITAE; and LEGUMINOSAE plant families. They can be activated in the liver by hydrolysis of the ester and desaturation of the necine base to reactive electrophilic pyrrolic CYTOTOXINS. Pyrrolizidine Alkaloid,Senecio Alkaloid,Senecio Alkaloids,Alkaloid, Pyrrolizidine,Alkaloid, Senecio,Alkaloids, Pyrrolizidine,Alkaloids, Senecio
D004952 Esters Compounds derived from organic or inorganic acids in which at least one hydroxyl group is replaced by an –O-alkyl or another organic group. They can be represented by the structure formula RCOOR’ and are usually formed by the reaction between an acid and an alcohol with elimination of water. Ester
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships

Related Publications

W M Hoskins, and D H Crout
Semisynthetic pyrrolizidine alkaloid N-oxide antitumor agents. Esters of heliotridine.
August 1988, Journal of medicinal chemistry,
W M Hoskins, and D H Crout
Carcinogenicity of some pyrrolic pyrrolizidine alkaloid metabolites and analogues.
October 1982, Cancer letters,
W M Hoskins, and D H Crout
Quantitative analysis of total retronecine esters-type pyrrolizidine alkaloids in plant by high performance liquid chromatography.
December 2007, Analytica chimica acta,
W M Hoskins, and D H Crout
Local anaesthetic action of some semisynthetic pyrrolizidine esters & their structure activity relationships.
January 1976, Indian journal of experimental biology,
W M Hoskins, and D H Crout
Recognition of pyrrolizidine alkaloid esters in the invasive aquatic plant Gymnocoronis spilanthoides (Asteraceae).
January 2015, Phytochemical analysis : PCA,
W M Hoskins, and D H Crout
Determination of total retronecine esters-type hepatotoxic pyrrolizidine alkaloids in plant materials by pre-column derivatization high-performance liquid chromatography.
June 2009, Biomedical chromatography : BMC,
W M Hoskins, and D H Crout
Hypotensive activity of semisynthetic pyrrolizidine amides.
May 1976, Indian journal of experimental biology,
W M Hoskins, and D H Crout
Pyrrolizidine alkaloid poisoning of horses.
March 1978, Australian veterinary journal,
W M Hoskins, and D H Crout
Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides.
October 2017, Journal of food and drug analysis,
W M Hoskins, and D H Crout
Pyrrolizidine alkaloid-derived DNA adducts as a common biological biomarker of pyrrolizidine alkaloid-induced tumorigenicity.
September 2013, Chemical research in toxicology,
Copied contents to your clipboard!