Biomaterial Database

Effects of the diuretics, triamterene and mersalyl on active sodium transport mechanisms in isolated frog skin. 1971

L A Salako, and A J Smith

1. Triamterene reduces the rate coefficients for sodium movement into the transporting system of the isolated frog skin. The isotopically measured ;active sodium transport pool' is also reduced.2. Mersalyl reduces the rate coefficient for sodium and the calculated sodium flux from the transporting system to the inner bathing solution. The ;active sodium transport pool' is increased by this diuretic.3. The action of triamterene closely resembles that of amiloride and both reduce the entry of sodium into the system. In contrast, mersalyl limits the exit of sodium ions from the skin.

UI	MeSH Term	Description	Entries
D009941	Organomercury Compounds	Organic compounds which contain mercury as an integral part of the molecule.	Compounds, Organomercury
D011719	Pyrazines	A heterocyclic aromatic organic compound with the chemical formula C4H4N2.	Pyrazine
D004232	Diuretics	Agents that promote the excretion of urine through their effects on kidney function.	Diuretic,Diuretic Effect,Diuretic Effects,Effect, Diuretic,Effects, Diuretic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001001	Anura	An order of the class Amphibia, which includes several families of frogs and toads. They are characterized by well developed hind limbs adapted for jumping, fused head and trunk and webbed toes. The term "toad" is ambiguous and is properly applied only to the family Bufonidae.	Bombina,Frogs and Toads,Salientia,Toad, Fire-Bellied,Toads and Frogs,Anuras,Fire-Bellied Toad,Fire-Bellied Toads,Salientias,Toad, Fire Bellied,Toads, Fire-Bellied
D001693	Biological Transport, Active	The movement of materials across cell membranes and epithelial layers against an electrochemical gradient, requiring the expenditure of metabolic energy.	Active Transport,Uphill Transport,Active Biological Transport,Biologic Transport, Active,Transport, Active Biological,Active Biologic Transport,Transport, Active,Transport, Active Biologic,Transport, Uphill
D012867	Skin	The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
D012964	Sodium	A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.	Sodium Ion Level,Sodium-23,Ion Level, Sodium,Level, Sodium Ion,Sodium 23
D012975	Sodium Isotopes	Stable sodium atoms that have the same atomic number as the element sodium, but differ in atomic weight. Na-23 is a stable sodium isotope.	Isotopes, Sodium
D014223	Triamterene	A pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.	Dyrenium,Dytac,Urocaudal