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A report is given on the spasmolytic effect of two benzisothiazolcarboxyamides (compound A and compound B). These drugs were able to inhibit the stimulant action of histamine on human isolated myometrium. The potency of the two compounds exceeded by ten times that of ritodrine (a beta adrenergic stimulant), the efficacy was slightly higher (20-30%) than that of papaverine. This pharmacological effect is discussed on the light of the spectrum of activites of the benzisothiazolcarboxyamidic compounds.
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