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In rats, intraventricularly injected antimelatonin antibody caused the appearance of transitory epileptiform abnormalities. Epileptic activity arose from and was limited to the cortical mantle of the hemisphere ipsilateral to the injection side. The occasional occurrence of lateralized seizures has also been observed. Control injection of saline, of the vehicle (rabbit serum), or of antibody saturated with melatonin induced flattening and desynchronization of the electroencephalogram but not epileptiform activity. Repeated antimelatonin injections caused reappearance of the same type of epileptic abnormalities that lasted slightly longer than the first time. Melatonin may play an inhibitory role in neuronal excitability.
R G Fariello, and
G A Bubenik, and
G M Brown, and
L J Grota
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R G Fariello, and
G A Bubenik, and
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L J Grota
November 1961,
Nature,
R G Fariello, and
G A Bubenik, and
G M Brown, and
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May 1977,
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R G Fariello, and
G A Bubenik, and
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R G Fariello, and
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R G Fariello, and
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L J Grota
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Neurochemical research,
R G Fariello, and
G A Bubenik, and
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L J Grota
January 2012,
Cell transplantation,
R G Fariello, and
G A Bubenik, and
G M Brown, and
L J Grota
September 2001,
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R G Fariello, and
G A Bubenik, and
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L J Grota
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R G Fariello, and
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