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A primary cutaneous lesion in a 5-year-old boy who had recently received chemotherapy for acute lymphocytic leukemia was found to be caused by a dematiaceous fungus, Drechslera spicifera. The lesion was an erythematous macule that rapidly developed necrotic ulcerations. The fungus, which is commonly found in soil and as a plant pathogen, was isolated from cultures of the lesion and from an excisional biopsy specimen. Hyphae and swollen hyphal cells resembling chlamydospores were observed in the biopsy specimen. Septate pigmented hyphae were found in the tissue, which is consistent with phaeohyphomycosis. Resolution of the infection occurred following excisional biopsy and systemic amphotericin B therapy. There was a concomitant recovery from neutropenia.
S A Estes, and
W G Merz, and
L G Maxwell
July 1975,
The Canadian veterinary journal = La revue veterinaire canadienne,
S A Estes, and
W G Merz, and
L G Maxwell
January 1975,
Journal of the American Veterinary Medical Association,
S A Estes, and
W G Merz, and
L G Maxwell
March 1982,
American journal of clinical pathology,
S A Estes, and
W G Merz, and
L G Maxwell
May 1984,
The Laryngoscope,
S A Estes, and
W G Merz, and
L G Maxwell
November 1975,
Sabouraudia,
S A Estes, and
W G Merz, and
L G Maxwell
May 1992,
European journal of epidemiology,
S A Estes, and
W G Merz, and
L G Maxwell
August 2011,
Transplant infectious disease : an official journal of the Transplantation Society,
S A Estes, and
W G Merz, and
L G Maxwell
September 2017,
Experimental and therapeutic medicine,
S A Estes, and
W G Merz, and
L G Maxwell
January 1986,
Pediatric infectious disease,
S A Estes, and
W G Merz, and
L G Maxwell
January 2008,
Acta dermato-venereologica,
