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A continuous blood sampling technique has been used to monitor human growth hormone (GH) during sleep in fourteen normal short children (age range 6.5-15.0 years), twelve hypopituitary children (2.8-17.3 years), three children with psychosocial GH deficiency (4.0-13.0 years), and three children with intrauterine growth retardation (9.5-11.3 years). The mean GH level of a 5 h sleep period (22.30-03.30 hours) was used to represent the GH response to sleep. The GH response to insulin induced hypoglycaemia (IST) was also determined. In normal short children there was a significant relationship between 5 h mean GH levels and chronological age. The curve defining this relationship was similar to the third centile linear growth velocity curve. The 5 h mean GH levels of the hypopituitary and psychosocial GH deficiency children were more than 2 SD below the age related mean established for normal short children. The children with intrauterine growth retardation demonstrated values which were more than 2 SD above the age related mean.
P M Howse, and
P H Rayner, and
J W Williams, and
B T Rudd, and
P V Bertrande, and
C R Thompson, and
L A Jones
January 1989,
Acta paediatrica Scandinavica. Supplement,
P M Howse, and
P H Rayner, and
J W Williams, and
B T Rudd, and
P V Bertrande, and
C R Thompson, and
L A Jones
January 1998,
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie,
P M Howse, and
P H Rayner, and
J W Williams, and
B T Rudd, and
P V Bertrande, and
C R Thompson, and
L A Jones
January 1996,
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie,
P M Howse, and
P H Rayner, and
J W Williams, and
B T Rudd, and
P V Bertrande, and
C R Thompson, and
L A Jones
January 1997,
Hormone research,
P M Howse, and
P H Rayner, and
J W Williams, and
B T Rudd, and
P V Bertrande, and
C R Thompson, and
L A Jones
January 1988,
Hormone research,
P M Howse, and
P H Rayner, and
J W Williams, and
B T Rudd, and
P V Bertrande, and
C R Thompson, and
L A Jones
January 1998,
Hormone research,
P M Howse, and
P H Rayner, and
J W Williams, and
B T Rudd, and
P V Bertrande, and
C R Thompson, and
L A Jones
January 1998,
Hormone research,
P M Howse, and
P H Rayner, and
J W Williams, and
B T Rudd, and
P V Bertrande, and
C R Thompson, and
L A Jones
January 1994,
Hormone research,
P M Howse, and
P H Rayner, and
J W Williams, and
B T Rudd, and
P V Bertrande, and
C R Thompson, and
L A Jones
April 1998,
The Journal of clinical endocrinology and metabolism,
P M Howse, and
P H Rayner, and
J W Williams, and
B T Rudd, and
P V Bertrande, and
C R Thompson, and
L A Jones
April 1994,
Acta paediatrica (Oslo, Norway : 1992). Supplement,
