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Daily treatment of female rats with medroxyprogesterone acetate in aqueous suspension resulted in adrenocortical atrophy. The doses given were those used for oestrus synchronisation. Intramuscular injections of 2-0 mg medroxyprogesterone acetate were used to investigate the atrophic process. Adrenocortical involution was associated with extensive single cell deletion (apoptosis). It is suggested that theses changes were due to suppression of pituitary ACTH secretion. The cytological changes support the concept that single cell death plays an important role in organ remodelling. Biochemical determinations of DNA, RNA, protein and dry matter, and histological examination, did not reveal significant changes in the liver.
B F Fell, and
R M Campbell, and
D Dinsdale
April 1978,
The Veterinary record,
B F Fell, and
R M Campbell, and
D Dinsdale
September 1978,
The Veterinary record,
B F Fell, and
R M Campbell, and
D Dinsdale
September 1979,
The Veterinary record,
B F Fell, and
R M Campbell, and
D Dinsdale
May 1967,
The Veterinary record,
B F Fell, and
R M Campbell, and
D Dinsdale
November 1971,
The Veterinary record,
B F Fell, and
R M Campbell, and
D Dinsdale
April 1978,
New Zealand veterinary journal,
B F Fell, and
R M Campbell, and
D Dinsdale
April 1978,
The Veterinary record,
B F Fell, and
R M Campbell, and
D Dinsdale
August 1998,
The Veterinary record,
B F Fell, and
R M Campbell, and
D Dinsdale
January 1969,
The Veterinary record,
B F Fell, and
R M Campbell, and
D Dinsdale
April 1967,
The Veterinary record,
