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In transplacental exposure to nitrosoethylurea in a dose of 2 mg/Kg the frequency of occurrence of different neoplasms in mice would not change as compared with a dose of 20 mg/Kg. However, in a dose of 2 mg/Kg the time of lung tumor development was prolonged. Postnatal roentgen irradiation increased the incidence of lung adenomas and ovarian tumors in female mice, exposed in embryogenesis to NEU effect in a dose of 2 mg/Kg; male mice showed a somewhat delayed development of tumors. In animals, subjected to NEU effect transplacentally in a dose of 20 mg/Kg, postnatal roentgen irradiation resulted in the appearance of lung adenocarcinomas, tumors of other lacolizations being developed neither in female nor in male mice.
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V I Kolodin
March 1981,
Cancer letters,
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January 1971,
Voprosy onkologii,
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January 1984,
Farmakologiia i toksikologiia,
N P Napalkov, and
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January 1976,
Acta poloniae pharmaceutica,
N P Napalkov, and
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October 1982,
Nihon juigaku zasshi. The Japanese journal of veterinary science,
N P Napalkov, and
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August 1992,
The Journal of veterinary medical science,
N P Napalkov, and
L Tomatis, and
A Ia Likhachev, and
V I Kolodin
January 1978,
Voprosy onkologii,
N P Napalkov, and
L Tomatis, and
A Ia Likhachev, and
V I Kolodin
July 1976,
Biulleten' eksperimental'noi biologii i meditsiny,
N P Napalkov, and
L Tomatis, and
A Ia Likhachev, and
V I Kolodin
March 1978,
Biulleten' eksperimental'noi biologii i meditsiny,
