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In the experiments on free behavior rabbits, tetanus toxin was injected into "pacemaker" motivational emotiogenic regions of the hypothalamus to form generators of pathologically enhanced excitation; this produced stable, long-term disorders in motivational-emotional behavior. The changes were manifested by intensification of the feeding behavior activity, including increase of the "secondary motivational reactions", intensification of the motor activity, excessive number of automatic masticatory movements, appearance of aggression, fear reaction and corresponding vegetative changes. The character of these reactions depended on the site of the toxin administration and on its dose. Formation of long-term generators of the pathologically enhanced excitation in the "pacemaker" motivational-emotiogenic centers of the hypothalamus by tetanus toxin can be used the modelling of psychopathological states in animals. The data obtained on the new model have confirmed the theory of generative mechanisms of neuropathological syndromes characterized by hyperactivity of the systems.
G N Kryzhanovskiĭ, and
A V Kotov, and
O A Kulygina, and
S M Tolpygo, and
K V Sudakov
May 1977,
Biulleten' eksperimental'noi biologii i meditsiny,
G N Kryzhanovskiĭ, and
A V Kotov, and
O A Kulygina, and
S M Tolpygo, and
K V Sudakov
October 1994,
Biulleten' eksperimental'noi biologii i meditsiny,
G N Kryzhanovskiĭ, and
A V Kotov, and
O A Kulygina, and
S M Tolpygo, and
K V Sudakov
January 1984,
Patologicheskaia fiziologiia i eksperimental'naia terapiia,
G N Kryzhanovskiĭ, and
A V Kotov, and
O A Kulygina, and
S M Tolpygo, and
K V Sudakov
October 1987,
Biulleten' eksperimental'noi biologii i meditsiny,
G N Kryzhanovskiĭ, and
A V Kotov, and
O A Kulygina, and
S M Tolpygo, and
K V Sudakov
December 1981,
Biulleten' eksperimental'noi biologii i meditsiny,
G N Kryzhanovskiĭ, and
A V Kotov, and
O A Kulygina, and
S M Tolpygo, and
K V Sudakov
November 1977,
Biulleten' eksperimental'noi biologii i meditsiny,
G N Kryzhanovskiĭ, and
A V Kotov, and
O A Kulygina, and
S M Tolpygo, and
K V Sudakov
January 1996,
Advances in neurology,
G N Kryzhanovskiĭ, and
A V Kotov, and
O A Kulygina, and
S M Tolpygo, and
K V Sudakov
January 1974,
Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952),
G N Kryzhanovskiĭ, and
A V Kotov, and
O A Kulygina, and
S M Tolpygo, and
K V Sudakov
August 1981,
Biulleten' eksperimental'noi biologii i meditsiny,
G N Kryzhanovskiĭ, and
A V Kotov, and
O A Kulygina, and
S M Tolpygo, and
K V Sudakov
October 1994,
Biulleten' eksperimental'noi biologii i meditsiny,
