Biomaterial Database

HLA antigen and susceptibility to leprosy. 1977

S Nakajima, and S Kobayashi, and M Nohara, and S Sato

Fifty-nine leprosy patients (31 tuberculoid, 28 lepromatous) have been HLA typed and compared to 125 healthy individuals who have had no known contact with leprosy patients in the past. HLA antigens were determined by the microdroplet lymphocyte toxicity method developed by Prof. Terasaki of UCLA. In order to detect 31 HLA antigens, a total of 58 antisera were used in a No. T-7 research tray. AW24 antigen showed the most remarkable deviation. The frequency of this antigen in leprosy patients was 25.4% and that in normal subjects of the control group was 63.2%. The difference in frequency between the two groups was statistically significant when the p value was corrected for the number of antigens being tested. Uncorrected p values of the BW39, A9, and B8 antigens were also statistically significant. Frequencies of the majority of HLA antigens in tuberculoid leprosy patients were similar to those of corresponding HLA antigens in lepromatous leprosy patients.

UI	MeSH Term	Description	Entries
D007113	Immunity, Innate	The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS.	Immunity, Native,Immunity, Natural,Immunity, Non-Specific,Resistance, Natural,Innate Immune Response,Innate Immunity,Immune Response, Innate,Immune Responses, Innate,Immunity, Non Specific,Innate Immune Responses,Native Immunity,Natural Immunity,Natural Resistance,Non-Specific Immunity
D007918	Leprosy	A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.	Hansen's Disease,Hansen Disease
D006680	HLA Antigens	Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.	Human Leukocyte Antigen,Human Leukocyte Antigens,Leukocyte Antigens,HL-A Antigens,Antigen, Human Leukocyte,Antigens, HL-A,Antigens, HLA,Antigens, Human Leukocyte,Antigens, Leukocyte,HL A Antigens,Leukocyte Antigen, Human,Leukocyte Antigens, Human
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

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