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Eight maturity-onset diabetic patients who had no infections, liver diseases or other endocrine diseases which might affect carbohydrate metabolism were treated with monocomponent lente insulin, which is known to have little antigenicity, until blood sugar was controlled. The diurnal values of the blood sugar (BS) and immunoreactive insulin (IRI) were obtained before treatment and on the third day after the withdrawal of insulin treatment. One patient was dropped from the study because of insulin antibody formation. The total integrated IRI area in the diurnal profile was increased from 98.9 +/- 23.7 to 186.1 +/- 37.7 muU.h/ml (p less than 0.05), while the total blood sugar area was decreased from 7,500 +/- 1,200 to 5,510 +/- 1,214 mg-h% (p less than 0.05). Oral Glucose Tolerance Test on the fourth day after the withdrawal of insulin treatment showed increased IRI response compared to pretreatment. It is concluded that endogenous insulin secretion could be increased in the diabetic patient by the metabolic control with exogenous insulin injections.
Y Fukumoto, and
K Ichihara, and
S Tarui
May 1973,
Wiener klinische Wochenschrift,
Y Fukumoto, and
K Ichihara, and
S Tarui
June 1974,
Diabetologia,
Y Fukumoto, and
K Ichihara, and
S Tarui
January 1984,
Minerva endocrinologica,
Y Fukumoto, and
K Ichihara, and
S Tarui
October 1984,
La Clinica terapeutica,
Y Fukumoto, and
K Ichihara, and
S Tarui
November 1976,
Lakartidningen,
Y Fukumoto, and
K Ichihara, and
S Tarui
November 1987,
Zhonghua nei ke za zhi,
Y Fukumoto, and
K Ichihara, and
S Tarui
October 1982,
Horumon to rinsho. Clinical endocrinology,
Y Fukumoto, and
K Ichihara, and
S Tarui
January 1974,
Ugeskrift for laeger,
Y Fukumoto, and
K Ichihara, and
S Tarui
April 1976,
Nederlands tijdschrift voor geneeskunde,
Y Fukumoto, and
K Ichihara, and
S Tarui
August 1985,
The Journal of the Association of Physicians of India,
