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cis- and trans-diamminedichloroplatinum(II) (PDD) produced a DNA cross-linking effect in mouse leukemia L1210 cells, which was demonstrable after subtoxic treatments with the DNA alkaline elution technique. Cross-linking effects developed following treatments with concentrations as low as 1 micron for cis-PDD and 5 micron for trans-PDD, which permitted over 80% survival of colony-forming ability. The maximum cross-linking effect by cis-PDD required about 12 hr of posttreatment incubation before it was fully developed, whereas the cross-linking effect of trans-PDD was fully developed at the end of the 1-hr drug exposure. The cross-linking effects of both agents were reversed upon further incubation of the cells.
L A Zwelling, and
K W Kohn, and
W E Ross, and
R A Ewig, and
T Anderson
May 1991,
Molecular biology reports,
L A Zwelling, and
K W Kohn, and
W E Ross, and
R A Ewig, and
T Anderson
January 1987,
Cancer research,
L A Zwelling, and
K W Kohn, and
W E Ross, and
R A Ewig, and
T Anderson
March 1982,
Chemico-biological interactions,
L A Zwelling, and
K W Kohn, and
W E Ross, and
R A Ewig, and
T Anderson
December 1985,
Cancer research,
L A Zwelling, and
K W Kohn, and
W E Ross, and
R A Ewig, and
T Anderson
April 1984,
Biochemistry,
L A Zwelling, and
K W Kohn, and
W E Ross, and
R A Ewig, and
T Anderson
April 1987,
Cancer research,
L A Zwelling, and
K W Kohn, and
W E Ross, and
R A Ewig, and
T Anderson
December 2000,
Biochemistry,
L A Zwelling, and
K W Kohn, and
W E Ross, and
R A Ewig, and
T Anderson
December 1987,
Cancer research,
L A Zwelling, and
K W Kohn, and
W E Ross, and
R A Ewig, and
T Anderson
January 1989,
Pharmacology & toxicology,
L A Zwelling, and
K W Kohn, and
W E Ross, and
R A Ewig, and
T Anderson
October 1996,
Nucleic acids research,
