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Daily profiles of plasma 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) were studied in four normal supine men on a normal sodium intake. Blood was taken every hour from 01.00 to 24.00 hours. Plasma cortisol (F) and aldosterone (A) were determined hourly for comparative studies. 18-OH-DOC fluctuated considerably during the 24 h period of investigation, the highest values being found during the early morning hours in synchrony with F. The episodic secretions of 18-OH-DOC were also significantly correlated with those of A, which in turn paralleled those of F. We conclude that ACTH, plays a definite role in the regulation of 18-OH-DOC in normal supine men on a normal sodium diet.
J Sulon, and
F Sparano, and
F Sciarra, and
G Giaquinto, and
P Genard
April 1978,
The Tohoku journal of experimental medicine,
J Sulon, and
F Sparano, and
F Sciarra, and
G Giaquinto, and
P Genard
February 1996,
Internal medicine (Tokyo, Japan),
J Sulon, and
F Sparano, and
F Sciarra, and
G Giaquinto, and
P Genard
November 1977,
Clinical science and molecular medicine,
J Sulon, and
F Sparano, and
F Sciarra, and
G Giaquinto, and
P Genard
July 1976,
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J Sulon, and
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P Genard
July 1972,
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J Sulon, and
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G Giaquinto, and
P Genard
May 1977,
Mayo Clinic proceedings,
J Sulon, and
F Sparano, and
F Sciarra, and
G Giaquinto, and
P Genard
February 1975,
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J Sulon, and
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P Genard
March 1995,
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J Sulon, and
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G Giaquinto, and
P Genard
November 1981,
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J Sulon, and
F Sparano, and
F Sciarra, and
G Giaquinto, and
P Genard
September 1976,
American journal of clinical pathology,
