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Friend leukemia cells were cultured in vitro in the presence or absence of agents which induce erythroid differentiation. The cultures were harvested and the degree of differentiation determined. Clonogenicity of the cells in vitro and malignancy in vivo were determined as well. There was an inverse exponential relationship between the degree of differentiation and the clonogenicity of the culture. Differentiation was also associated with a modest decline in malignancy. Of interest was the observation that bromodeoxyuridine inhibited the biochemical manifestations of erythroid differentiation, but did not prevent the decline in clonogenicity which accompanied differentiation.
H D Preisler, and
G Christoff, and
P Reese, and
P Pavelic, and
Y Rustum
December 1975,
Cell differentiation,
H D Preisler, and
G Christoff, and
P Reese, and
P Pavelic, and
Y Rustum
January 1975,
Bibliotheca haematologica,
H D Preisler, and
G Christoff, and
P Reese, and
P Pavelic, and
Y Rustum
September 1980,
Developmental biology,
H D Preisler, and
G Christoff, and
P Reese, and
P Pavelic, and
Y Rustum
April 1981,
Biochimica et biophysica acta,
H D Preisler, and
G Christoff, and
P Reese, and
P Pavelic, and
Y Rustum
February 1980,
Gan,
H D Preisler, and
G Christoff, and
P Reese, and
P Pavelic, and
Y Rustum
February 1979,
Gan,
H D Preisler, and
G Christoff, and
P Reese, and
P Pavelic, and
Y Rustum
November 1982,
Zhonghua Minguo wei sheng wu ji mian yi xue za zhi = Chinese journal of microbiology and immunology,
H D Preisler, and
G Christoff, and
P Reese, and
P Pavelic, and
Y Rustum
September 1988,
Shi yan sheng wu xue bao,
H D Preisler, and
G Christoff, and
P Reese, and
P Pavelic, and
Y Rustum
June 1978,
Journal of cellular physiology,
H D Preisler, and
G Christoff, and
P Reese, and
P Pavelic, and
Y Rustum
February 1986,
Nihon rinsho. Japanese journal of clinical medicine,
