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Serum concentrations of lipid-soluble (glycolipid) sialic acid were determined for 96 client-owned dogs, of which 24 were diagnosed as bearing tumors. A markedly increased concentration of lipid-soluble serum sialic acid was found in 22 of 24 tumor-bearing dogs (92%) compared with 17 of 72 dogs with other definitely false-positive, based on necropsy and follow-up work. Almost all others had acute infections or terminal congestive disorders and were potential tumor bearers. The values obtained appeared to be independent of the sex or age (or both) of the dogs. Based on the analysis of a single biochemical variable, the procedure may permit cancer detection applicable to a wide range of tumor types in dogs if evaluated in terms of the general health status of the animal.
T M Kloppel, and
C P Franz, and
D J Morré, and
R C Richardson
July 1977,
Proceedings of the National Academy of Sciences of the United States of America,
T M Kloppel, and
C P Franz, and
D J Morré, and
R C Richardson
November 2007,
The Tohoku journal of experimental medicine,
T M Kloppel, and
C P Franz, and
D J Morré, and
R C Richardson
January 2013,
Scientia pharmaceutica,
T M Kloppel, and
C P Franz, and
D J Morré, and
R C Richardson
September 1970,
Indian journal of biochemistry,
T M Kloppel, and
C P Franz, and
D J Morré, and
R C Richardson
January 1989,
Biomedica biochimica acta,
T M Kloppel, and
C P Franz, and
D J Morré, and
R C Richardson
April 2019,
Interface focus,
T M Kloppel, and
C P Franz, and
D J Morré, and
R C Richardson
July 1990,
Journal of postgraduate medicine,
T M Kloppel, and
C P Franz, and
D J Morré, and
R C Richardson
November 1963,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
T M Kloppel, and
C P Franz, and
D J Morré, and
R C Richardson
June 2012,
Veterinary and comparative oncology,
T M Kloppel, and
C P Franz, and
D J Morré, and
R C Richardson
May 1971,
American journal of veterinary research,
