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The direct action of arginine-vasopressin (AVP) and its deamino-D-arginine analogue (DDAVP) on renin release (RR) has been studied in isolated rat kidneys perfused with an electrolyte solution at constant pressure in a single-pass system. AVP and DDAVP infused at various concentrations (80 to 2100 pg/ml and 80 to 8700 pg/ml, respectively) reduced volume and increased osmolality of urine in a dose-dependent way. High doses of AVP reduced renal perfusate flow and glomerular filtration rate while DDAVP had no effect on renal haemodynamics. When vasoconstrictor doses of AVP or high concentrations of DDAVP were infused, "basal" RR remained unchanged. However, when RR had been stimulated by infusion of isoproterenol, vasoconstrictor doses of AVP as well as high doses of DDAVP which did not increase renal vascular resistance diminished RR by about 30% (P less than 0.01, and P less than 0.05, respectively). These results suggest that the inhibition of RR by vasopressin is not related to its vasoconstrictor action.
A Konrads, and
K G Hofbauer, and
U Werner, and
F Gross
September 1979,
Experientia,
A Konrads, and
K G Hofbauer, and
U Werner, and
F Gross
June 1976,
Journal of medicinal chemistry,
A Konrads, and
K G Hofbauer, and
U Werner, and
F Gross
August 1992,
The American journal of physiology,
A Konrads, and
K G Hofbauer, and
U Werner, and
F Gross
June 1983,
Endocrinologia experimentalis,
A Konrads, and
K G Hofbauer, and
U Werner, and
F Gross
January 1980,
Progress in biochemical pharmacology,
A Konrads, and
K G Hofbauer, and
U Werner, and
F Gross
January 1975,
Naunyn-Schmiedeberg's archives of pharmacology,
A Konrads, and
K G Hofbauer, and
U Werner, and
F Gross
October 1982,
European journal of pharmacology,
A Konrads, and
K G Hofbauer, and
U Werner, and
F Gross
June 1982,
Naunyn-Schmiedeberg's archives of pharmacology,
A Konrads, and
K G Hofbauer, and
U Werner, and
F Gross
March 1987,
Japanese heart journal,
A Konrads, and
K G Hofbauer, and
U Werner, and
F Gross
July 1983,
Kidney international,
