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The narcotic antagonist, naloxone, was microinjected into the head of the caudate nucleus (HC), periaqueductal gray matter (PG), and cerebellar white matter (CB) of rats to counteract the catatonia induced by systemic morphine. Naloxone produced a loss of the catatonic response when administered into HC or PG, but not when microinjected into CB. Isotonic saline in HC, PG, and CB did not counteract the catatonic effects of morphine. The reversal of catatonia was similar for naloxone injections in HC and PG. Both these areas have high concentrations of opiate receptors while CB has few opiate receptors. It is suggested that the HC and PG are involved in the reversal of the catatonic effects of morphine via the high concentrations of opiate receptors found there.
R E Wilcox, and
R A Levitt
February 2011,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
R E Wilcox, and
R A Levitt
November 1998,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
R E Wilcox, and
R A Levitt
April 1998,
Behavioural brain research,
R E Wilcox, and
R A Levitt
November 1974,
Life sciences,
R E Wilcox, and
R A Levitt
January 1979,
Research communications in chemical pathology and pharmacology,
R E Wilcox, and
R A Levitt
November 1988,
Behavioural brain research,
R E Wilcox, and
R A Levitt
October 1987,
European journal of pharmacology,
R E Wilcox, and
R A Levitt
January 1992,
Peptides,
R E Wilcox, and
R A Levitt
February 1992,
Brain research bulletin,
R E Wilcox, and
R A Levitt
January 1987,
Life sciences,
