The clinicopathological features of 29 patients with nodular sclerosing Hodgkin's disease are described. The histological appearances are those of a nodular pattern due to thick fibrous bands which encircle areas of abnormal lymphoid tissue in which a particular form of abnormal reticulum cell can be recognized. They can be further subdivided into well differentiated and poorly differentiated types; the median survival time from onset in the well differentiated type was approximately nine years and in the poorly differentiated type two years. The outstanding clinical feature of patients with the well differentiated histological pattern was repeated enlargements of various groups of lymph glands over long periods of time.