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The effect of acute and chronic ethanol intake on hepatic glycerolipid biosynthesis in the hamster was studied by in vivo and in vitro techniques. The results were compared with those from control hamsters receiving isocaloric amounts of glucose. Both chronic and acute ethanol intake elevated serum and hepatic triglyceride concentrations and induced a rapid rise in the capacity of neutral glycerolipid formation from sn[1,3-14C]glycerol-3-phosphate by hamster liver homogenate and microsomal fractions. Ethanol intake also produced a corresponding increase in the incorporation of [1,3-14C]glycerol into hepatic neutral glycerolipids by the intact animal. The ethanol-induced rise in the capacity of neutral glycerolipid production by liver as measured in vivo and in vitro correlated well with an increase in hepatic phosphatidate phosphohydrolase activity. Therefore, the rise in hepatic and serum triglyceride levels associated with ethanol intake may be explained in part by an increase in the activity of the enzyme.
R G Lamb, and
C K Wood, and
H J Fallon
January 1980,
Advances in experimental medicine and biology,
R G Lamb, and
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H J Fallon
December 1979,
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R G Lamb, and
C K Wood, and
H J Fallon
December 1969,
Biochimica et biophysica acta,
R G Lamb, and
C K Wood, and
H J Fallon
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Biochimica et biophysica acta,
R G Lamb, and
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H J Fallon
June 1977,
The Journal of nutrition,
R G Lamb, and
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H J Fallon
December 2010,
Biochimica et biophysica acta,
R G Lamb, and
C K Wood, and
H J Fallon
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Digestive diseases and sciences,
R G Lamb, and
C K Wood, and
H J Fallon
January 1983,
Pharmacology, biochemistry, and behavior,
R G Lamb, and
C K Wood, and
H J Fallon
August 1987,
Archives of biochemistry and biophysics,
R G Lamb, and
C K Wood, and
H J Fallon
March 1990,
The American journal of physiology,
