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To clarify the mechanism for the coexistence of ovarian and testicular tissue in the 46,XX true hermaphrodite, we studied a 20-year-old phenotypic male with gynecomastia and elevated serum concentrations of estradiol in whom an ovotestis was discovered upon scrotal exploration. Y chromosomal material could not be detected by fluorescent Y-body analysis or Giemsa-banding technics in cells cultured from peripheral blood, breast or forearm skin or the ovarian or testicular portions of the ovotestis. However, serologic testing, using the sperm cytotoxicity assay, revealed that cells cultured from the testicular portion of the ovotestis were H-Y antigen positive whereas cells cultured from the ovarian portion were H-Y antigen negative. These observations indicate that the ovotestis arises from an H-Y+/H-Y- mosaic primordium.
S J Winters, and
S S Wachtel, and
B J White, and
G C Koo, and
N Javadpour, and
D L Loriaux, and
R J Sherins
May 1986,
Hinyokika kiyo. Acta urologica Japonica,
S J Winters, and
S S Wachtel, and
B J White, and
G C Koo, and
N Javadpour, and
D L Loriaux, and
R J Sherins
March 1984,
Cancer,
S J Winters, and
S S Wachtel, and
B J White, and
G C Koo, and
N Javadpour, and
D L Loriaux, and
R J Sherins
June 1975,
Lancet (London, England),
S J Winters, and
S S Wachtel, and
B J White, and
G C Koo, and
N Javadpour, and
D L Loriaux, and
R J Sherins
January 1971,
The Indian journal of medical research,
S J Winters, and
S S Wachtel, and
B J White, and
G C Koo, and
N Javadpour, and
D L Loriaux, and
R J Sherins
November 2010,
Fertility and sterility,
S J Winters, and
S S Wachtel, and
B J White, and
G C Koo, and
N Javadpour, and
D L Loriaux, and
R J Sherins
April 1982,
Cancer,
S J Winters, and
S S Wachtel, and
B J White, and
G C Koo, and
N Javadpour, and
D L Loriaux, and
R J Sherins
March 1971,
Journal of medical genetics,
S J Winters, and
S S Wachtel, and
B J White, and
G C Koo, and
N Javadpour, and
D L Loriaux, and
R J Sherins
May 1965,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
S J Winters, and
S S Wachtel, and
B J White, and
G C Koo, and
N Javadpour, and
D L Loriaux, and
R J Sherins
September 2000,
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology,
S J Winters, and
S S Wachtel, and
B J White, and
G C Koo, and
N Javadpour, and
D L Loriaux, and
R J Sherins
March 2009,
Urology,
