Biomaterial Database

Stereotypic and hypothermic effects of apomorphine and N-n-propylnorapomorphine in mice. 1979

W H Riffee, and R E Wilcox, and R V Smith

Two dopaminergic agonists, apomorphine (APO) and N-n-propylnorapomorphine (NPA) were compared in mice for their ability to induce stereotypic cage-climbing and hypothermia. Stereotypic cage-climbing responses were recorded on videotape and subsequently rated "blind" in comparison to the animal's predrug behavior and to the behavior of animals administered control solutions. Hypothermia was measured as changes from predug body temperature. Both APO and NPA produced statistically significant cage-climbing and hypothermia vs. controls. Dose-response analyses (0.5-10 mg/kg, i.p.) indicated that on a milligram basis the two drugs induced similar magnitudes of stereotypic activity. In contrast, dose-response analyses (0.008-40 mg/kg, i.p.) of APO and NPA induced hypothermia suggested an approximate 90-fold greater effect for NPA. These results suggest that there may be two different types of dopaminergic systems responsible for the hypothermic and stereotypic responses measured.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D001831	Body Temperature	The measure of the level of heat of a human or animal.	Organ Temperature,Body Temperatures,Organ Temperatures,Temperature, Body,Temperature, Organ,Temperatures, Body,Temperatures, Organ
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001058	Apomorphine	A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.	Apokinon,Apomorphin-Teclapharm,Apomorphine Chloride,Apomorphine Hydrochloride,Apomorphine Hydrochloride Anhydrous,Apomorphine Hydrochloride, Anhydrous,Apomorphine Hydrochloride, Hemihydrate,Britaject,Apomorphin Teclapharm
D001519	Behavior	The observable response of a man or animal to a situation.	Acceptance Process,Acceptance Processes,Behaviors,Process, Acceptance,Processes, Acceptance
D013239	Stereotyped Behavior	Relatively invariant mode of behavior elicited or determined by a particular situation; may be verbal, postural, or expressive.	Behavior, Stereotyped,Behaviors, Stereotyped,Stereotyped Behaviors
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus