Biomaterial Database

A histological comparison of contracted and non-contracted capsules around silicone breast implants. 1979

R M Gayou

A single blind comparison of capsular tissue obtained from both breasts from 7 patients in whom unilateral contracture had occurred leads to the following conclusions: (1) The presence of droplets (presumed to be silicone, or extractable silicone as identified by IR) in capsular tissue does not correlate with the clinical finding of firmness. (2) Contracted capsules are apt to be significantly more cellular, largely as a result of an increased fibroblast population. (3) The apparent severity of inflammation in a biopsy of a capsule does not correlate with the clinical degree of firmness in the breast. (4) In the 7 cases studied, capsule thickness or vascularity, collagen alignment, staining uptake, presence of foreign bodies, or presence of an inner cell layer of macrophages did not correlate with the clinical finding of firmness.

UI	MeSH Term	Description	Entries
D008264	Macrophages	The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)	Bone Marrow-Derived Macrophages,Monocyte-Derived Macrophages,Macrophage,Macrophages, Monocyte-Derived,Bone Marrow Derived Macrophages,Bone Marrow-Derived Macrophage,Macrophage, Bone Marrow-Derived,Macrophage, Monocyte-Derived,Macrophages, Bone Marrow-Derived,Macrophages, Monocyte Derived,Monocyte Derived Macrophages,Monocyte-Derived Macrophage
D008408	Mastectomy	Surgical procedure to remove one or both breasts.	Mammectomy,Mammectomies,Mastectomies
D008413	Mastitis	INFLAMMATION of the BREAST, or MAMMARY GLAND.
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D001940	Breast	In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.	Breasts
D001941	Breast Diseases	Pathological processes of the BREAST.	Endocrine Breast Diseases,Breast Disease,Breast Disease, Endocrine,Breast Diseases, Endocrine,Disease, Breast,Disease, Endocrine Breast,Diseases, Breast,Diseases, Endocrine Breast,Endocrine Breast Disease
D003286	Contracture	Prolonged shortening of the muscle or other soft tissue around a joint, preventing movement of the joint.	Contractures
D005260	Female		Females
D005347	Fibroblasts	Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.	Fibroblast
D005782	Gels	Colloids with a solid continuous phase and liquid as the dispersed phase; gels may be unstable when, due to temperature or other cause, the solid phase liquefies; the resulting colloid is called a sol.