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Populations of G1-phase Chinese hamster cells in stirred suspensions containing various concentrations of DMSO were irradiated with 250 kV X-rays or various heavy charged-particle beams. Chemical radioprotection of cell inactivation was observed for all LET values studied. When cell survival data were resolved into linear and quadratic components, the extent and concentration dependence of DMSO protection were found to be different for the two mechanisms. The chemical kinetics of radioprotection for single-events were similar for LET values up to those which gave the maximum RBE. DMSO protected to a lesser extent against energetic argon ions at an median LET of approximately 220 keV/micron. These data could indicate the contribution of indirect action by hydroxyl radicals and hydrogen atoms to cell inactivation by single-hit and double-hit mechanisms for various radiation qualities. The decrease in RBE observed at very high LET may result, in part, from reduced yields of water radicals at 10(-9)-10(-8) s resulting from radical recombination mechanisms within the charged particle tracks.
J D Chapman, and
S D Doern, and
A P Reuvers, and
C J Gillespie, and
A Chatterjee, and
E A Blakely, and
K C Smith, and
C A Tobias
January 2002,
Advances in space research : the official journal of the Committee on Space Research (COSPAR),
J D Chapman, and
S D Doern, and
A P Reuvers, and
C J Gillespie, and
A Chatterjee, and
E A Blakely, and
K C Smith, and
C A Tobias
May 1968,
Radiation research,
J D Chapman, and
S D Doern, and
A P Reuvers, and
C J Gillespie, and
A Chatterjee, and
E A Blakely, and
K C Smith, and
C A Tobias
December 1982,
International journal of radiation oncology, biology, physics,
J D Chapman, and
S D Doern, and
A P Reuvers, and
C J Gillespie, and
A Chatterjee, and
E A Blakely, and
K C Smith, and
C A Tobias
February 2005,
International journal of radiation biology,
J D Chapman, and
S D Doern, and
A P Reuvers, and
C J Gillespie, and
A Chatterjee, and
E A Blakely, and
K C Smith, and
C A Tobias
June 1994,
Radiation research,
J D Chapman, and
S D Doern, and
A P Reuvers, and
C J Gillespie, and
A Chatterjee, and
E A Blakely, and
K C Smith, and
C A Tobias
January 1987,
Radiation research,
J D Chapman, and
S D Doern, and
A P Reuvers, and
C J Gillespie, and
A Chatterjee, and
E A Blakely, and
K C Smith, and
C A Tobias
February 1969,
The British journal of radiology,
J D Chapman, and
S D Doern, and
A P Reuvers, and
C J Gillespie, and
A Chatterjee, and
E A Blakely, and
K C Smith, and
C A Tobias
May 2019,
Radiation protection dosimetry,
J D Chapman, and
S D Doern, and
A P Reuvers, and
C J Gillespie, and
A Chatterjee, and
E A Blakely, and
K C Smith, and
C A Tobias
September 2015,
Radiation protection dosimetry,
J D Chapman, and
S D Doern, and
A P Reuvers, and
C J Gillespie, and
A Chatterjee, and
E A Blakely, and
K C Smith, and
C A Tobias
February 1980,
International journal of radiation biology and related studies in physics, chemistry, and medicine,
