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Concentrations of 27 commonly estimated serum constituents were measured in blood sampled from 20 apparently healthy volunteers at 0830, 1230, and 1630 hours on each of four days, at weekly intervals. Time-dependent statistically significant (p less than or equal to 0.01) variation was observed in 12 of the constituents. The 15 constituents that showed no statistically significant diurnal variation included the immunoglobulins, other specific proteins, enzymes, cholesterol, calcium, copper, and magnesium. On the different days of the study consistent temporal patterns were observed in urea, creatinine, phosphate, zinc, bilirubin, triglyceride, total protein, and albumin. The magnitude of variation was particularly great in potassium, iron, zinc, and bilirubin. In general, day-to-day changes in concentration exceeded within-day changes, except for potassium, phosphate, and zinc, for which greater changes could be observed within-day than from one day to another at the same time.
B Morrison, and
A Shenkin, and
A McLelland, and
D A Robertson, and
M Barrowman, and
S Graham, and
G Wuga, and
K J Cunningham
May 1987,
Clinical chemistry,
B Morrison, and
A Shenkin, and
A McLelland, and
D A Robertson, and
M Barrowman, and
S Graham, and
G Wuga, and
K J Cunningham
December 1973,
Clinical chemistry,
B Morrison, and
A Shenkin, and
A McLelland, and
D A Robertson, and
M Barrowman, and
S Graham, and
G Wuga, and
K J Cunningham
December 1973,
Clinical chemistry,
B Morrison, and
A Shenkin, and
A McLelland, and
D A Robertson, and
M Barrowman, and
S Graham, and
G Wuga, and
K J Cunningham
December 1974,
Clinical chemistry,
B Morrison, and
A Shenkin, and
A McLelland, and
D A Robertson, and
M Barrowman, and
S Graham, and
G Wuga, and
K J Cunningham
December 1974,
Clinical chemistry,
B Morrison, and
A Shenkin, and
A McLelland, and
D A Robertson, and
M Barrowman, and
S Graham, and
G Wuga, and
K J Cunningham
May 1977,
Clinical chemistry,
B Morrison, and
A Shenkin, and
A McLelland, and
D A Robertson, and
M Barrowman, and
S Graham, and
G Wuga, and
K J Cunningham
July 1989,
Clinical chemistry,
B Morrison, and
A Shenkin, and
A McLelland, and
D A Robertson, and
M Barrowman, and
S Graham, and
G Wuga, and
K J Cunningham
October 1988,
Clinical chemistry,
B Morrison, and
A Shenkin, and
A McLelland, and
D A Robertson, and
M Barrowman, and
S Graham, and
G Wuga, and
K J Cunningham
January 1983,
Scandinavian journal of rheumatology,
B Morrison, and
A Shenkin, and
A McLelland, and
D A Robertson, and
M Barrowman, and
S Graham, and
G Wuga, and
K J Cunningham
December 1974,
Clinical chemistry,
