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Chronically alcoholized intoxication (1.5--2 months) induces adaptation of cerebral neurones to changing equilibrium states of biochemical processes by altering the activity of enzymes of GABA metabolism, reduction of alanine and aspartate transaminase activity and increase of LDH and succinate dehydrogenase activity. In the cerebellum and cerebral hemispheres during alcohol abstinacy the activity of GABA-T, succinate dehydrogenase and aspartate transaminase was reduced while that of LDH and alanine transaminase was increased. The administration of fusarinic acid (100 mg/kg i. p.) to control animals induced a sharp increase of GAD activity in both structures of the brain. The stimulatory effects of fusarinic acid were not observed when it was administered to animals receiving alcohol chronically. Motor activity or rats was markedly reduced during chronical alcoholism and the first days of alcohol abstinacy (24--48 h), as well as following injection fusarinic acid and homopantothenic acid. The increase of locomotion and the vertical component of motor activity was observed only following one week or one month after alcohol abstinacy.
I A Sytinskiĭ, and
A M Bezborodov, and
O E Blagova, and
N N Konovalova, and
V M Kopelevich
January 1972,
Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952),
I A Sytinskiĭ, and
A M Bezborodov, and
O E Blagova, and
N N Konovalova, and
V M Kopelevich
January 1992,
Voprosy meditsinskoi khimii,
I A Sytinskiĭ, and
A M Bezborodov, and
O E Blagova, and
N N Konovalova, and
V M Kopelevich
January 1984,
Sudebno-meditsinskaia ekspertiza,
I A Sytinskiĭ, and
A M Bezborodov, and
O E Blagova, and
N N Konovalova, and
V M Kopelevich
December 1982,
Vrachebnoe delo,
I A Sytinskiĭ, and
A M Bezborodov, and
O E Blagova, and
N N Konovalova, and
V M Kopelevich
December 1982,
Vrachebnoe delo,
I A Sytinskiĭ, and
A M Bezborodov, and
O E Blagova, and
N N Konovalova, and
V M Kopelevich
June 2000,
Alcoholism, clinical and experimental research,
I A Sytinskiĭ, and
A M Bezborodov, and
O E Blagova, and
N N Konovalova, and
V M Kopelevich
April 2008,
Vnitrni lekarstvi,
I A Sytinskiĭ, and
A M Bezborodov, and
O E Blagova, and
N N Konovalova, and
V M Kopelevich
June 1975,
Vrachebnoe delo,
I A Sytinskiĭ, and
A M Bezborodov, and
O E Blagova, and
N N Konovalova, and
V M Kopelevich
January 1972,
Eksperimentalna meditsina i morfologiia,
I A Sytinskiĭ, and
A M Bezborodov, and
O E Blagova, and
N N Konovalova, and
V M Kopelevich
January 1984,
Sovetskaia meditsina,
