Biomaterial Database

Diurnal expiratory flow after inhalation of Freons and fenoterol in childhood asthma. 1979

V Graff-Lonnevig

Eighteen children aged 8 to 14 years with bronchial asthma were studied with respect to the diurnal variation in pulmonary expiratory flow and the influence on it of inhalation of Freons and of a beta 2-receptor stimulator, fenoterol. A double-blind technique and randomized order of the different conditions were used. Dynamic spirometric tests were performed every hour from 8 A.M. to 4 P.M. The low expiratory flow in the morning increased during the day and influenced the estimated duration of the beta 2-receptor stimulator. This must be taken into consideration when evaluating the long-term effect of bronchodilator drugs. The Freons acted as irritants and lowered the expiratory flow during the first 2 hr after inhalation. However, this impairment of lung function does not seem to be of any clinical importance when freons are used as propellants for potent beta 2-receptor stimulators such as fenoterol.

UI	MeSH Term	Description	Entries
D008168	Lung	Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.	Lungs
D008297	Male		Males
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002940	Circadian Rhythm	The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli.	Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D004311	Double-Blind Method	A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.	Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D004983	Ethanolamines	AMINO ALCOHOLS containing the ETHANOLAMINE; (-NH2CH2CHOH) group and its derivatives.	Aminoethanols
D005260	Female		Females
D005280	Fenoterol	A synthetic adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic.	Berotec,Berotek,Fenoterol Hydrobromide,Fenoterol Hydrochloride,Partusisten,Phenoterol,Th-1165a,p-Hydroxyphenyl-orciprenaline,p-Hydroxyphenylorciprenaline,Hydrochloride, Fenoterol,Th 1165a,Th1165a,p Hydroxyphenyl orciprenaline,p Hydroxyphenylorciprenaline
D005540	Forced Expiratory Flow Rates	The rate of airflow measured during a FORCED VITAL CAPACITY determination.	Expiratory Forced Flow Rates,Flow Rates, Expiratory Forced,Flow Rates, Forced Expiratory
D005617	Chlorofluorocarbons, Methane	A group of methane-based halogenated hydrocarbons containing one or more fluorine and chlorine atoms.	Fluorocarbon Aerosols,Fluorocarbon Propellants,Chlorofluoromethanes,Aerosols, Fluorocarbon,Methane Chlorofluorocarbons,Propellants, Fluorocarbon