-transparent.png){kind=logo}
Antagonism by neostigmine of neuromuscular blockade produced by pancuronium or its metabolites was studied in the cat anterior or tibialis muscle-peroneal nerve preparation using constant infusions of muscle relaxants. The ED50 of neostigmine (dose which caused a 50% antagonism) was 16, 11, 29, and 26 micrograms/kg for pancuronium, 3-hydroxypancuronium, 17-hydroxypancuronium, and 3, 17-hydroxypancuronium, respectively. Times of onset of neostigmine action were shorter when antagonizing 17-hydroxypancuronium neuromuscular blockade. Duration of neostigmine action when antagonizing 17- or 3, 17-hydroxypancuronium blockade was shorter than with pancuronium or 3-hydroxypancuronium. We conclude that more neostigmine is required to antagonize 17- or 3,17-hydroxypancuronium neuromuscular blockade than is required to antagonize pancuronium. Conversely, less neostigmine was required to antagonize 3-hydroxypancuronium blockade.
L H Booij, and
R D Miller, and
M J Jones, and
D R Stanski
June 1978,
British journal of anaesthesia,
L H Booij, and
R D Miller, and
M J Jones, and
D R Stanski
May 1977,
Anesthesiology,
L H Booij, and
R D Miller, and
M J Jones, and
D R Stanski
June 1994,
Masui. The Japanese journal of anesthesiology,
L H Booij, and
R D Miller, and
M J Jones, and
D R Stanski
January 1982,
British journal of anaesthesia,
L H Booij, and
R D Miller, and
M J Jones, and
D R Stanski
April 1978,
British journal of anaesthesia,
L H Booij, and
R D Miller, and
M J Jones, and
D R Stanski
April 1982,
British journal of anaesthesia,
L H Booij, and
R D Miller, and
M J Jones, and
D R Stanski
November 1987,
European journal of anaesthesiology,
L H Booij, and
R D Miller, and
M J Jones, and
D R Stanski
February 1993,
British journal of anaesthesia,
L H Booij, and
R D Miller, and
M J Jones, and
D R Stanski
November 1972,
Anesthesiology,
L H Booij, and
R D Miller, and
M J Jones, and
D R Stanski
December 1976,
Anesthesiology,
