BIOMAT Database Logo BIOMAT Database Logo

Localisation of the NADPH delta 4-3-keto steroid-5 alpha-oxidoreductase in the rat ovary. 1979

P R Koninckx, and P De Moor

The 5 alpha-reductase activity was localised on the stromal comportment of the rat ovary. The 5 alpha-reductase activity in stromal tissue decreased from 27.3 +/- 2.9 ng/hr/mg protein in rats 20 days old, to 13.4 +/- 1.2 ng/hr/mg protein in rats 30 days old and to 7.1 +/- 1.0 ng/hr/mg protein in adult rats. During the oestrous cycle no significant variations in enzyme activity could be demonstrated.

UI MeSH Term Description Entries
D010053 Ovary The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE. Ovaries
D010088 Oxidoreductases The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9) Dehydrogenases,Oxidases,Oxidoreductase,Reductases,Dehydrogenase,Oxidase,Reductase
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D004971 Estrus The period in the ESTROUS CYCLE associated with maximum sexual receptivity and fertility in non-primate female mammals.
D005260 Female Females
D000375 Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. Senescence,Aging, Biological,Biological Aging
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013741 3-Oxo-5-alpha-Steroid 4-Dehydrogenase An enzyme that catalyzes the reduction of TESTOSTERONE to 5-ALPHA DIHYDROTESTOSTERONE. 3-Keto-5-alpha-Steroid delta-4-Dehydrogenase,5-alpha-Reductase, Testosterone,Testosterone 5-alpha-Reductase,Testosterone delta-4-5-alpha-Reductase,3-oxo-5 alpha-Steroid 4-Dehydrogenase (NADP+),3-oxo-5alpha-Steroid 4-Dehydrogenase (NADP+),4-Ene-3-Oxosteroid-5alpha-Reductase,4-Ene-5-alpha-Reductase,NADH-5-alpha-Reductase,NADPH delta(4)-3-Ketosteroid 5 alpha-Oxidoreductase,Steroid 5-alpha-Reductase,Steroid 5Alpha Reductase,Steroid delta-4-5-alpha Reductase,delta 4-3-keto Steroid 5 alpha-Oxidoreductase,delta(4)-3-Ketosteroid-5alpha-Reductase,delta4-3-ketosteroid 5alpha-Oxidoreductase,3 Keto 5 alpha Steroid delta 4 Dehydrogenase,3 Oxo 5 alpha Steroid 4 Dehydrogenase,4 Ene 3 Oxosteroid 5alpha Reductase,4 Ene 5 alpha Reductase,5 alpha Reductase, Testosterone,5-alpha-Reductase, Steroid,5Alpha Reductase, Steroid,5alpha-Oxidoreductase, delta4-3-ketosteroid,NADH 5 alpha Reductase,Reductase, Steroid 5Alpha,Reductase, Steroid delta-4-5-alpha,Steroid 5 alpha Reductase,Steroid delta 4 5 alpha Reductase,Testosterone 5 alpha Reductase,Testosterone delta 4 5 alpha Reductase,delta 4 3 keto Steroid 5 alpha Oxidoreductase,delta-4-5-alpha Reductase, Steroid,delta-4-5-alpha-Reductase, Testosterone,delta-4-Dehydrogenase, 3-Keto-5-alpha-Steroid,delta4 3 ketosteroid 5alpha Oxidoreductase
D015096 3-Hydroxysteroid Dehydrogenases Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids. 3-beta-Hydroxysteroid Dehydrogenase,3 Hydroxysteroid Dehydrogenases,3 beta Hydroxysteroid Dehydrogenase,Dehydrogenase, 3-beta-Hydroxysteroid,Dehydrogenases, 3 Hydroxysteroid,Dehydrogenases, 3-Hydroxysteroid,Hydroxysteroid Dehydrogenases, 3
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

P R Koninckx, and P De Moor
3-keto-5 alpha-steroid-delta 4-dehydrogenase from Nocardia corallina: purification and characterization.
April 1991, Journal of biochemistry,
P R Koninckx, and P De Moor
Purification and properties of 3 alpha-hydroxysteroid dehydrogenase and 3-keto-5 beta-steroid-delta 4-dehydrogenase.
December 1998, Annals of the New York Academy of Sciences,
P R Koninckx, and P De Moor
[Substrate specificity of delta 4-3-ketosteroid:NADPH-oxidoreductase (5 alpha) from rat liver microsomes].
January 1969, Biokhimiia (Moscow, Russia),
P R Koninckx, and P De Moor
delta 4-3-Ketosteroid 5 alpha-oxidoreductase in human uterine leiomyoma.
October 1979, American journal of obstetrics and gynecology,
P R Koninckx, and P De Moor
Synthesis of 5-alpha,6,6-trifluoro-3-keto and 6,6-difluoro-delta-4-3-keto steroids.
April 1966, The Journal of organic chemistry,
P R Koninckx, and P De Moor
Steroid delta 4-5 alpha-reductase and 3 alpha-hydroxysteroid dehydrogenase in the rat epididymis during development.
October 1980, Endocrinology,
P R Koninckx, and P De Moor
Purification of the NADPH:5 alpha-dihydroprogesterone 3 alpha-hydroxysteroid oxidoreductase from female rat pituitary cytosol.
October 1990, The Journal of steroid biochemistry and molecular biology,
P R Koninckx, and P De Moor
[3 beta-hydroxy-delta 5-C27-steroid-oxidoreductase/isomerase deficiency].
January 1998, Ryoikibetsu shokogun shirizu,
P R Koninckx, and P De Moor
3-keto-delta-4 steroid: requirement for ovulation in Rana pipiens.
June 1971, General and comparative endocrinology,
P R Koninckx, and P De Moor
Inhibition by a 4-methyl-4-aza-steroid of NADPH: delta 4-3-oxosteroid-5 alpha-oxido-reductase activity in cultured interstitial cells derived from immature rat testis.
March 1983, Journal of steroid biochemistry,
Copied contents to your clipboard!