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An epizootic disease characterized by failure to gain weight, lethargy, enteropathy, and death developed in weanlings from a production colony of NIH/Nmri CV mice. Light microscopic and scanning electron microscopic examination of the intestine revealed large numbers of protozoan parasites identified as Spironucleus (Hexamita) muris. The extensive, entangled mass of organisms in the intestinal lumen enveloped the villi and continued deep within the crypts of Lieberkühn. Inflammation and significant intestinal lesions were not observed. The scanning electron microscopic appearance of the small intestine in spironucleosis gives credence to a pathogenesis of malabsorption with subsequent, severe malnutrition and death in weanling mice.
D L Eisenbrandt, and
R J Russell
July 1977,
Laboratory animals,
D L Eisenbrandt, and
R J Russell
May 1993,
Australian veterinary journal,
D L Eisenbrandt, and
R J Russell
October 1979,
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie,
D L Eisenbrandt, and
R J Russell
December 1983,
Parasitology,
D L Eisenbrandt, and
R J Russell
February 1984,
Experimental parasitology,
D L Eisenbrandt, and
R J Russell
January 1976,
Zeitschrift fur Versuchstierkunde,
D L Eisenbrandt, and
R J Russell
April 1980,
Laboratory animals,
D L Eisenbrandt, and
R J Russell
June 1998,
Veterinary parasitology,
D L Eisenbrandt, and
R J Russell
January 1996,
The Journal of eukaryotic microbiology,
D L Eisenbrandt, and
R J Russell
January 1972,
Laboratory animals,
