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Two groups of 23 patients, each with acute myocardial infarction, were treated. The first group (control) received glucose-insuline-K+ (GIK) over a 3-day period, and the second GIK and N-methyl-N-(beta-hydroxyethyl) guanidine O-phosphate (creatinol O-phosphate, COP) (3.06 g i.v./24 h), again for a 3-day period. The six enzymes investigated, i. e. GOT, GPT, LDH, HBDH, CK and MBCK, all decreased between 33 and 49% in the COP group as compared with the control group, reaching a degree of statistical significance of less than 0.01. The decrease in these enzymes was attributed to the protective action of COP on the cell membrane permeability, in agreement with a series of previous papers.
M Knippel, and
G Bana, and
G L Pusterla
January 1979,
Arzneimittel-Forschung,
M Knippel, and
G Bana, and
G L Pusterla
January 1971,
Bollettino della Societa italiana di cardiologia,
M Knippel, and
G Bana, and
G L Pusterla
December 1965,
Il Farmaco; edizione scientifica,
M Knippel, and
G Bana, and
G L Pusterla
August 1972,
Bollettino della Societa italiana di biologia sperimentale,
M Knippel, and
G Bana, and
G L Pusterla
September 1972,
La Clinica terapeutica,
M Knippel, and
G Bana, and
G L Pusterla
January 1979,
Indian heart journal,
M Knippel, and
G Bana, and
G L Pusterla
April 2000,
Indian journal of physiology and pharmacology,
M Knippel, and
G Bana, and
G L Pusterla
December 1970,
Il Farmaco; edizione scientifica,
M Knippel, and
G Bana, and
G L Pusterla
June 1971,
Archives internationales de pharmacodynamie et de therapie,
M Knippel, and
G Bana, and
G L Pusterla
October 1982,
American heart journal,
