Biomaterial Database

Catecholamine and 5-hydroxyindole metabolism in immunosympathectomized rats. 1969

P M Ceasar, and C R Ruthven, and M Sandler

1. The daily urinary excretion of normetadrenaline, metadrenaline, 4-hydroxy-3-methoxyphenylglycol, 4-hydroxy-3-methoxymandelic acid, dopamine, homovanillic acid, 5-hydroxytryptamine and 5-hydroxyindolylacetic acid has been estimated in the urine of immunosympathectomized and control rats.2. A method is given which allows separate spectrophotometric determination of 4-hydroxy-3-methoxyphenylglycol and 4-hydroxy-3-methoxymandelic acid in the same sample of rat urine. Metadrenaline and normetadrenaline were estimated by a modification of the method of Anton & Sayre (1966).3. Approximately 17% of the 4-hydroxy-3-methoxymandelic acid in rat urine is excreted in the free state, over 60% as a glucuronide conjugate and the remainder as a sulphate conjugate.4. Urinary excretion of 4-hydroxy-3-methoxyphenylglycol was approximately halved in immunosympathectomized rats (P<0.001). 4-Hydroxy-3-methoxymandelic acid output was significantly increased in treated animals (P<0.05) when expressed in terms of body weight. No significant difference was detected for any of the other compounds investigated.5. The results are discussed in the light of previous knowledge of the effect of immunosympathectomy on catecholamine metabolism.

UI	MeSH Term	Description	Entries
D007106	Immune Sera	Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.	Antisera,Immune Serums,Sera, Immune,Serums, Immune
D007211	Indoles	Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
D008297	Male		Males
D009414	Nerve Growth Factors	Factors which enhance the growth potentialities of sensory and sympathetic nerve cells.	Neurite Outgrowth Factor,Neurite Outgrowth Factors,Neuronal Growth-Associated Protein,Neuronotrophic Factor,Neurotrophic Factor,Neurotrophic Factors,Neurotrophin,Neurotrophins,Growth-Associated Proteins, Neuronal,Neuronal Growth-Associated Proteins,Neuronotrophic Factors,Neurotrophic Protein,Neurotrophic Proteins,Proteins, Neuronal Growth-Associated,Factor, Neurite Outgrowth,Factor, Neuronotrophic,Factor, Neurotrophic,Factors, Nerve Growth,Factors, Neurite Outgrowth,Factors, Neuronotrophic,Factors, Neurotrophic,Growth Associated Proteins, Neuronal,Growth-Associated Protein, Neuronal,Neuronal Growth Associated Protein,Neuronal Growth Associated Proteins,Outgrowth Factor, Neurite,Outgrowth Factors, Neurite,Protein, Neuronal Growth-Associated
D009647	Normetanephrine	A methylated metabolite of norepinephrine that is excreted in the urine and found in certain tissues. It is a marker for tumors.	3-Methoxynoradrenaline,Normetadrenaline,3 Methoxynoradrenaline
D010627	Phenethylamines	A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed)	Phenylethylamines
D002395	Catecholamines	A general class of ortho-dihydroxyphenylalkylamines derived from TYROSINE.	Catecholamine,Sympathin,Sympathins
D005260	Female		Females
D005725	Ganglia, Autonomic	Clusters of neurons and their processes in the autonomic nervous system. In the autonomic ganglia, the preganglionic fibers from the central nervous system synapse onto the neurons whose axons are the postganglionic fibers innervating target organs. The ganglia also contain intrinsic neurons and supporting cells and preganglionic fibers passing through to other ganglia.	Autonomic Ganglia,Ganglion, Autonomic,Autonomic Ganglion
D006897	Hydroxyindoleacetic Acid		5-HIAA,5-Hydroxy-3-Indoleacetic Acid,5-Hydroxyindolamine Acetic Acid,5 Hydroxy 3 Indoleacetic Acid,5 Hydroxyindolamine Acetic Acid,Acetic Acid, 5-Hydroxyindolamine,Acid, 5-Hydroxy-3-Indoleacetic,Acid, 5-Hydroxyindolamine Acetic,Acid, Hydroxyindoleacetic