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Göttingen miniature pigs were used to test a combination of the active principles coumarin and troxerutin (Venalot) for teratogenic and embryotoxiic side-effects. The experimental group consisted of 17 mother pigs with 95 fetuses, the control group of 6 untreated sows with 45 fetuses. The combination of coumarin and troxerutin was administered orally at a level of the 100-fold therapeutic dose (i.e. 25 mg coumarin + 150 mg troxertutin/kg/day) from day 6 to day 30 of gestation. The pathological and histological examinations of the uteri and fetuses revealed no indications of any embryotoxic or teratogenic damage caused by the tested combinations. Morphological and clinico-chemical investigations did also not result in any findings definitely attributable to the medication.
W Grote, and
L C Schulz, and
W Drommer, and
S Uberschär, and
E A Schäfer
October 1975,
Arzneimittel-Forschung,
W Grote, and
L C Schulz, and
W Drommer, and
S Uberschär, and
E A Schäfer
October 1981,
Jikken dobutsu. Experimental animals,
W Grote, and
L C Schulz, and
W Drommer, and
S Uberschär, and
E A Schäfer
September 1976,
Sbornik lekarsky,
W Grote, and
L C Schulz, and
W Drommer, and
S Uberschär, and
E A Schäfer
October 1979,
Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology,
W Grote, and
L C Schulz, and
W Drommer, and
S Uberschär, and
E A Schäfer
January 1980,
Arzneimittel-Forschung,
W Grote, and
L C Schulz, and
W Drommer, and
S Uberschär, and
E A Schäfer
March 1982,
DTW. Deutsche tierarztliche Wochenschrift,
W Grote, and
L C Schulz, and
W Drommer, and
S Uberschär, and
E A Schäfer
July 1977,
Arzneimittel-Forschung,
W Grote, and
L C Schulz, and
W Drommer, and
S Uberschär, and
E A Schäfer
July 1974,
Hu li za zhi The journal of nursing,
W Grote, and
L C Schulz, and
W Drommer, and
S Uberschär, and
E A Schäfer
October 1984,
Wiadomosci lekarskie (Warsaw, Poland : 1960),
W Grote, and
L C Schulz, and
W Drommer, and
S Uberschär, and
E A Schäfer
January 1981,
Therapie,
