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Absorption and urinary excretion of pivampicillin as hydrochloride and as base were studied following administration of four different formulations to 12 healthy volunteers in a cross-over study. A fluorimetric assay of ampicillin was adapted to be used with an Auto Analyzer system. The plasma concentrations observed are comparable to those reported in the literature. The amount of drug absorbed is the same for all four medications whereas absorption is more rapid from tablets than from capsules. Base and hydrochloride of pivampicillin are equivalent with respect to pharmacokinetic behaviour. So, the formulation itself seems to be more important for biological equivalence than the ionisation of the drug used in the formulation.
V Fedorcak, and
H Mielenz, and
G Bozler
February 1974,
Medizinische Klinik,
V Fedorcak, and
H Mielenz, and
G Bozler
October 1979,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
V Fedorcak, and
H Mielenz, and
G Bozler
August 1977,
The Japanese journal of antibiotics,
V Fedorcak, and
H Mielenz, and
G Bozler
May 1976,
The Japanese journal of antibiotics,
V Fedorcak, and
H Mielenz, and
G Bozler
September 1974,
Archiv der Pharmazie,
V Fedorcak, and
H Mielenz, and
G Bozler
March 1974,
Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis,
V Fedorcak, and
H Mielenz, and
G Bozler
January 1975,
Arzneimittel-Forschung,
V Fedorcak, and
H Mielenz, and
G Bozler
July 1983,
Die Pharmazie,
V Fedorcak, and
H Mielenz, and
G Bozler
December 1974,
Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis,
V Fedorcak, and
H Mielenz, and
G Bozler
May 1981,
Yao xue xue bao = Acta pharmaceutica Sinica,
