-transparent.png){kind=logo}
Lidoflazine was metabolized very rapidly by 16000 g supernatant fractions of rat and dog liver. The rate and the extent of metabolism were considerably superior for rat liver. Lidoflazine metabolites were purified by extraction and thin-layer chromatography and identified by mass spectrometry. The main pathways of the in vitro metabolism by rat and dog liver fractions were the same. Oxidative N-dealkylation was the most important. An incubation of major metabolite 1-[4,4-bis(4-fluorophenyl)-butyl]piperazine, with rat liver fraction was performed. A hydroxylated metabolite and a ketopiperazine metabolite were detected only in the dog experiments.
Related Publications
W Meuldermans, and
W Lauwers, and
A Knaeps, and
J Heykants
February 2017,
Yao xue xue bao = Acta pharmaceutica Sinica,
W Meuldermans, and
W Lauwers, and
A Knaeps, and
J Heykants
January 1980,
Drug metabolism and disposition: the biological fate of chemicals,
W Meuldermans, and
W Lauwers, and
A Knaeps, and
J Heykants
January 1982,
Cancer research,
W Meuldermans, and
W Lauwers, and
A Knaeps, and
J Heykants
April 1968,
Acta endocrinologica,
W Meuldermans, and
W Lauwers, and
A Knaeps, and
J Heykants
April 1978,
Toxicology and applied pharmacology,
W Meuldermans, and
W Lauwers, and
A Knaeps, and
J Heykants
October 1996,
Xenobiotica; the fate of foreign compounds in biological systems,
W Meuldermans, and
W Lauwers, and
A Knaeps, and
J Heykants
December 1961,
Biochimica et biophysica acta,
W Meuldermans, and
W Lauwers, and
A Knaeps, and
J Heykants
March 1961,
Report. Army Medical Research Laboratory (U.S.),
W Meuldermans, and
W Lauwers, and
A Knaeps, and
J Heykants
January 1986,
Drug metabolism and disposition: the biological fate of chemicals,
W Meuldermans, and
W Lauwers, and
A Knaeps, and
J Heykants
February 1981,
Pharmacological research communications,
