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An 18 year old girl is reported, who ingested 15 g of primidone (Liskantin), 330 mg/kg, to commit suicide. Continuous monitoring of the serum levels of primidone, PEMA, and phenobarbital revealed increased elimination of primidone by forced diuresis (6000 ml/24 hours). It is concluded that forced diuresis inhibits the otherwise mandatory increase in primidone metabolites, PEMA and phenobarbital. It is suggested that even after improvement of the clinical symptoms forced diuresis should be continued for at least 48 hours. In epileptic patients the reinstitution of primidone therapy should be considered only on the third day after accidental ingestion, if the clinical symptoms have improved, and if there is no possibility of immediate determination of primidone serum levels.
I Lagenstein, and
H J Sternowsky, and
E Iffland, and
E Blaschke
January 1975,
The Netherlands journal of medicine,
I Lagenstein, and
H J Sternowsky, and
E Iffland, and
E Blaschke
March 1965,
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I Lagenstein, and
H J Sternowsky, and
E Iffland, and
E Blaschke
November 1983,
Canadian Medical Association journal,
I Lagenstein, and
H J Sternowsky, and
E Iffland, and
E Blaschke
October 1978,
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I Lagenstein, and
H J Sternowsky, and
E Iffland, and
E Blaschke
May 1964,
Lancet (London, England),
I Lagenstein, and
H J Sternowsky, and
E Iffland, and
E Blaschke
January 1984,
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I Lagenstein, and
H J Sternowsky, and
E Iffland, and
E Blaschke
January 1965,
Clinical pharmacology and therapeutics,
I Lagenstein, and
H J Sternowsky, and
E Iffland, and
E Blaschke
November 1982,
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I Lagenstein, and
H J Sternowsky, and
E Iffland, and
E Blaschke
March 1946,
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I Lagenstein, and
H J Sternowsky, and
E Iffland, and
E Blaschke
February 1980,
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