-transparent.png){kind=logo}
Human fibrinogen and purified plasmic degradation fragments X (stages 1 and 2), D and E were labelled with 125-I using the lactoperoxidase method. The chromatographic, electrophoretic and immunologic properties of the labelled proteins were found to be similar to those of non-labelled fragments. All the degradation products diffused rapidly (T 1/2 0.27-0.75 hours) from the intravascular space of rabbits, as compared with fibrinogen (4.26 hours). In addition, the metabolic half-life was found to be 49.3 hours for fibrinogen, as compared with only 5.6, 6.1, 2.3 and 1.4 for fragments X (stage 1), X (stage 2), D and E, respectively. The metabolic half-life roughly reflects the molecular size of the degradation products.
N Ardaillou, and
L Dray, and
A Z Budzynski, and
V J Marder, and
M J Larrieu
May 1972,
Biochimica et biophysica acta,
N Ardaillou, and
L Dray, and
A Z Budzynski, and
V J Marder, and
M J Larrieu
June 1975,
Blood,
N Ardaillou, and
L Dray, and
A Z Budzynski, and
V J Marder, and
M J Larrieu
January 1971,
Scandinavian journal of haematology. Supplementum,
N Ardaillou, and
L Dray, and
A Z Budzynski, and
V J Marder, and
M J Larrieu
April 1975,
Thrombosis et diathesis haemorrhagica,
N Ardaillou, and
L Dray, and
A Z Budzynski, and
V J Marder, and
M J Larrieu
April 1974,
The Journal of biological chemistry,
N Ardaillou, and
L Dray, and
A Z Budzynski, and
V J Marder, and
M J Larrieu
December 1983,
The Journal of laboratory and clinical medicine,
N Ardaillou, and
L Dray, and
A Z Budzynski, and
V J Marder, and
M J Larrieu
August 1975,
Biochimica et biophysica acta,
N Ardaillou, and
L Dray, and
A Z Budzynski, and
V J Marder, and
M J Larrieu
November 1976,
The Journal of laboratory and clinical medicine,
N Ardaillou, and
L Dray, and
A Z Budzynski, and
V J Marder, and
M J Larrieu
February 1977,
Thrombosis and haemostasis,
N Ardaillou, and
L Dray, and
A Z Budzynski, and
V J Marder, and
M J Larrieu
October 1973,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
