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Thallium-201 has been suggested as a useful diagnostic agent for myocardial scanning. We report herewith the clinical usefulness of Tl-201 as a result of our animal studies with rats as well as clinical trial for human being. After intravenous injection, we killed rats at regular intervals, then measured the activity in each anatomized organ by gamma-well counter and observed the internal distribution and examined autoradiograms with the naked eye. As a result, the accumulation of Tl=201 in the myocardium observed in 5 min after injection, reaching the maximum level in 30 min and gradually decreased hereafter. We performed 22 myocardial clinical scans. In adults we could clearly detect the lesion of myocardial infarction, but in children found it difficult to obtain full sufficient information due to small heart size and high pulse rate. Judging from the foregoing we think it possible to obtain much clearer images by using a data analyzer.
K Ishii, and
T Kobayashi, and
T Matsubayashi, and
K Nakazawa, and
K Yoda
January 1981,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
K Ishii, and
T Kobayashi, and
T Matsubayashi, and
K Nakazawa, and
K Yoda
January 1981,
Methods in enzymology,
K Ishii, and
T Kobayashi, and
T Matsubayashi, and
K Nakazawa, and
K Yoda
January 1981,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
K Ishii, and
T Kobayashi, and
T Matsubayashi, and
K Nakazawa, and
K Yoda
December 1970,
Food and cosmetics toxicology,
K Ishii, and
T Kobayashi, and
T Matsubayashi, and
K Nakazawa, and
K Yoda
April 2000,
Regulatory toxicology and pharmacology : RTP,
K Ishii, and
T Kobayashi, and
T Matsubayashi, and
K Nakazawa, and
K Yoda
March 1997,
Nuclear medicine communications,
K Ishii, and
T Kobayashi, and
T Matsubayashi, and
K Nakazawa, and
K Yoda
October 2002,
Current drug metabolism,
K Ishii, and
T Kobayashi, and
T Matsubayashi, and
K Nakazawa, and
K Yoda
July 1975,
Stain technology,
K Ishii, and
T Kobayashi, and
T Matsubayashi, and
K Nakazawa, and
K Yoda
January 1983,
Critical reviews in toxicology,
K Ishii, and
T Kobayashi, and
T Matsubayashi, and
K Nakazawa, and
K Yoda
February 1984,
The International journal of applied radiation and isotopes,
