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Mammary gland explants obtained from 13 days pregnant rats were cultured for 3, 6 and 9 days in the presence of serum of either virgin rats or 13 days pregnant rats. Insulin was added alone or in combination with cortisol. The way these different forms of treatment affected the ultrastructure was studied. With virgin rat serum plus insulin alone the mammary gland regressed to a lower state of development comparable to that of the virgin rat in vivo. When virgin rat serum was replaced by 13 days pregnant rat serum--which contains rat chorionic mammotrophin--the initial development was maintained, but synthesis of secretory products ceased. When cortisol was added to the virgin rat serum plus insulin, cortisol maintained the differentiated state originally present. Even some secretory activity was induced, but at a minimal level. With cortisol added to the pregnant rat serum plus insulin, the explants were stimulated to synthetize the extrude secretion products.
K D Njio, and
J M Peters
June 1972,
Archives internationales de pharmacodynamie et de therapie,
K D Njio, and
J M Peters
March 1971,
The Journal of endocrinology,
K D Njio, and
J M Peters
December 1969,
Archives internationales de pharmacodynamie et de therapie,
K D Njio, and
J M Peters
July 1959,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
K D Njio, and
J M Peters
July 1966,
Laboratory investigation; a journal of technical methods and pathology,
K D Njio, and
J M Peters
May 1970,
The Journal of experimental zoology,
K D Njio, and
J M Peters
January 1987,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
K D Njio, and
J M Peters
April 1964,
Laboratory investigation; a journal of technical methods and pathology,
K D Njio, and
J M Peters
January 1973,
In vitro,
K D Njio, and
J M Peters
January 1964,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
