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Compared to the changes in spontaneous behaviour of mice and rats, 6-(3-[4-(o-methoxyphenyl)-1-piperazinyl]-propyl-amino)-1,3-dimethyluracil (urapidil, Ebrantil) in doses from 10 mg/kg p.o. has a central sedative action, for which it is typical that it can be interrupted by external stimuli after doses of up to approx. 100 mg/kg. By this action urapidil differs from other central-acting drugs, e.g. chlor-promazine, diazepam and clonidine. It can be assumed that urapidil has no central dopamine blocking qualities because it does neither influence the conditioned avoidance response nor the amphetamine-induced gnawing of the rat. Urapidil is also different from diazepam bacause it does not hinder spinal polysynaptic motor reflexes of the decerebrated cat. Up to 80 mg/kg p.o. of urapidil, there was no hypotensive effect in the rat to be seen and, therefore, it can be concluded that changes in spontaneous and reactive behaviour are not due to acute changes in cardiovascular functions. The antihistamine effect of urapidil in the isolated ileum of the guinea pig is approx. 15 times weaker than that of chlorpromazine, furthermore urapidil has no anticholinergic quality.
W Schoetensack, and
M Eltze, and
S Gönne, and
K P Kley, and
H G Menge, and
H Müller
January 1977,
Arzneimittel-Forschung,
W Schoetensack, and
M Eltze, and
S Gönne, and
K P Kley, and
H G Menge, and
H Müller
February 1979,
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica,
W Schoetensack, and
M Eltze, and
S Gönne, and
K P Kley, and
H G Menge, and
H Müller
November 1968,
Arzneimittel-Forschung,
W Schoetensack, and
M Eltze, and
S Gönne, and
K P Kley, and
H G Menge, and
H Müller
December 1980,
Yao xue xue bao = Acta pharmaceutica Sinica,
W Schoetensack, and
M Eltze, and
S Gönne, and
K P Kley, and
H G Menge, and
H Müller
May 1980,
Klinika oczna,
W Schoetensack, and
M Eltze, and
S Gönne, and
K P Kley, and
H G Menge, and
H Müller
October 1980,
Lijecnicki vjesnik,
W Schoetensack, and
M Eltze, and
S Gönne, and
K P Kley, and
H G Menge, and
H Müller
January 1977,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
W Schoetensack, and
M Eltze, and
S Gönne, and
K P Kley, and
H G Menge, and
H Müller
November 1980,
Lijecnicki vjesnik,
W Schoetensack, and
M Eltze, and
S Gönne, and
K P Kley, and
H G Menge, and
H Müller
January 1976,
Nippon Ganka Gakkai zasshi,
W Schoetensack, and
M Eltze, and
S Gönne, and
K P Kley, and
H G Menge, and
H Müller
March 1954,
Doklady Akademii nauk SSSR,
