[Pharmacology and toxicology of etofenamate. 1st Communication (author's transl)]. 1977

H Jacobi, and P Breier, and H D Dell, and D Lorenz

1. The reliable antiphlogistic action of 2-(2-hydroxyethoxy)-ethyl-N-(a,a,a-trifluoro-m-tolyl)-anthranilate (etofenamate active principle of Rheumon Gel) in various experimental inflammatory models in animals is demonstrated following oral and cutaneous administration. 2. The proven inhibition of inflammatory edema by chronic administration of Rheumon gel evidences the percutaneous absorption of the active principle through the intact skin. 3. The effect of Rheumon gel sets in independently of whether the gel is applied to normal or to pathologically inflamed tissue areas. 4. Gastrointestinal mucous tolerance is better for etofenamate than for flufenamic acid, phenylbutazone and other anti-inflammatory drugs.

UI MeSH Term Description Entries
D008297 Male Males
D004353 Drug Evaluation, Preclinical Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications. Drug Screening,Evaluation Studies, Drug, Pre-Clinical,Drug Evaluation Studies, Preclinical,Drug Evaluations, Preclinical,Evaluation Studies, Drug, Preclinical,Evaluation, Preclinical Drug,Evaluations, Preclinical Drug,Medicinal Plants Testing, Preclinical,Preclinical Drug Evaluation,Preclinical Drug Evaluations,Drug Screenings,Screening, Drug,Screenings, Drug
D004487 Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE. Dropsy,Hydrops,Anasarca
D005260 Female Females
D005439 Flufenamic Acid An anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically. (From Martindale, The Extra Pharmacopoeia, 30th ed, p16) Dignodolin,Acid, Flufenamic
D006168 Guinea Pigs A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research. Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

H Jacobi, and P Breier, and H D Dell, and D Lorenz
January 1977, Arzneimittel-Forschung,
H Jacobi, and P Breier, and H D Dell, and D Lorenz
December 1981, Praxis und Klinik der Pneumologie,
H Jacobi, and P Breier, and H D Dell, and D Lorenz
January 1978, Arzneimittel-Forschung,
H Jacobi, and P Breier, and H D Dell, and D Lorenz
October 1981, Planta medica,
H Jacobi, and P Breier, and H D Dell, and D Lorenz
November 1981, Planta medica,
H Jacobi, and P Breier, and H D Dell, and D Lorenz
January 1981, Arzneimittel-Forschung,
H Jacobi, and P Breier, and H D Dell, and D Lorenz
April 1974, Humangenetik,
H Jacobi, and P Breier, and H D Dell, and D Lorenz
January 1978, Arzneimittel-Forschung,
H Jacobi, and P Breier, and H D Dell, and D Lorenz
January 1977, Arzneimittel-Forschung,
H Jacobi, and P Breier, and H D Dell, and D Lorenz
January 1977, Arzneimittel-Forschung,
Copied contents to your clipboard!