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15 mg trans-4-[2-amino-3,5-dibromo-benzyl)-amino]-cyclohexanol-hydrochloride (ambroxol, NA 872) was administered i.v. and orally to healthy volunteers. The metabolic pattern in urine and plasma was similar for both routes of administration. Biotransformation reactions are straightforward, yielding two major products of phage I reactions identified as 6,8-dibromo-3-(trans-4-hydroxycyclohexyl)-1,2,3,4-tetrahydro-quinazoline and 3,5-dibromo-anthranilic acid. These metabolites as well as the parent compound are also converted to conjugates, predominantly glucuronides. Quantification of unlabelled ambroxol in biological fluids is achieved by radiochemical derivatisation with 14C-labelled formaldehyde in imitation of the biotransformation.
R Jauch, and
G Bozler, and
R Hammer, and
F W Koss, and
M Karlsson, and
E Vitek, and
I Häring, and
K Beschke, and
S Hadamovsky, and
D Maass, and
R Wollmann
January 1976,
Arzneimittel-Forschung,
R Jauch, and
G Bozler, and
R Hammer, and
F W Koss, and
M Karlsson, and
E Vitek, and
I Häring, and
K Beschke, and
S Hadamovsky, and
D Maass, and
R Wollmann
January 1978,
Arzneimittel-Forschung,
R Jauch, and
G Bozler, and
R Hammer, and
F W Koss, and
M Karlsson, and
E Vitek, and
I Häring, and
K Beschke, and
S Hadamovsky, and
D Maass, and
R Wollmann
December 1975,
Zeitschrift fur Lebensmittel-Untersuchung und -Forschung,
R Jauch, and
G Bozler, and
R Hammer, and
F W Koss, and
M Karlsson, and
E Vitek, and
I Häring, and
K Beschke, and
S Hadamovsky, and
D Maass, and
R Wollmann
January 1977,
Arzneimittel-Forschung,
R Jauch, and
G Bozler, and
R Hammer, and
F W Koss, and
M Karlsson, and
E Vitek, and
I Häring, and
K Beschke, and
S Hadamovsky, and
D Maass, and
R Wollmann
January 1980,
Die Pharmazie,
R Jauch, and
G Bozler, and
R Hammer, and
F W Koss, and
M Karlsson, and
E Vitek, and
I Häring, and
K Beschke, and
S Hadamovsky, and
D Maass, and
R Wollmann
January 1981,
Arzneimittel-Forschung,
R Jauch, and
G Bozler, and
R Hammer, and
F W Koss, and
M Karlsson, and
E Vitek, and
I Häring, and
K Beschke, and
S Hadamovsky, and
D Maass, and
R Wollmann
January 1977,
Arzneimittel-Forschung,
R Jauch, and
G Bozler, and
R Hammer, and
F W Koss, and
M Karlsson, and
E Vitek, and
I Häring, and
K Beschke, and
S Hadamovsky, and
D Maass, and
R Wollmann
January 1976,
Arzneimittel-Forschung,
R Jauch, and
G Bozler, and
R Hammer, and
F W Koss, and
M Karlsson, and
E Vitek, and
I Häring, and
K Beschke, and
S Hadamovsky, and
D Maass, and
R Wollmann
January 1980,
Arzneimittel-Forschung,
R Jauch, and
G Bozler, and
R Hammer, and
F W Koss, and
M Karlsson, and
E Vitek, and
I Häring, and
K Beschke, and
S Hadamovsky, and
D Maass, and
R Wollmann
January 1978,
Arzneimittel-Forschung,
