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Rat intestinal disaccharidase activities were investigated during treatment with different doses of 2-[bis-(2-chlorethyl)-amino]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide (cyclophosphamide). In all experiments, disaccharidase activities decreased--although not too drastically--within 2--3 days after beginning treatment. Loss of activity was not reversed during the period of experimentation. Contrary to previous investigations, cyclophosphamide did not exert direct toxic effects on intestinal disaccharidases. Decrease of intestinal disaccharidase activities can be interpreted to be due to cyclophosphamide effects on the proliferation cycle of epithelial crypt cells resulting in a decreased number of full-function cells.
G Hartwich, and
K Weisshaar, and
W Domschke
December 1973,
Ceskoslovenska gastroenterologie a vyziva,
G Hartwich, and
K Weisshaar, and
W Domschke
February 1976,
Arzneimittel-Forschung,
G Hartwich, and
K Weisshaar, and
W Domschke
October 1974,
Klinische Wochenschrift,
G Hartwich, and
K Weisshaar, and
W Domschke
January 1976,
Arzneimittel-Forschung,
G Hartwich, and
K Weisshaar, and
W Domschke
January 1978,
Arquivos de gastroenterologia,
G Hartwich, and
K Weisshaar, and
W Domschke
October 1973,
Sbornik lekarsky,
G Hartwich, and
K Weisshaar, and
W Domschke
November 1975,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
G Hartwich, and
K Weisshaar, and
W Domschke
January 1969,
Revista portuguesa de pediatria e puericultura,
G Hartwich, and
K Weisshaar, and
W Domschke
January 1980,
Anatomischer Anzeiger,
G Hartwich, and
K Weisshaar, and
W Domschke
January 1975,
Journal of nutritional science and vitaminology,
