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The effect of ovine prolactin administration on the fetal rabbit pulmonary pressure volume relationship was determined. Using pentobarbital anesthesia, on Day 24 of gestation, a midline incision on the maternal abdomen was made to expose the bicornuate uterus. Fetal rabbits in one horn of the uterus were injected intramuscularly with a dose of 1.0 mg (0.05 ml) of prolactin solution. Similarly, fetuses in the opposite horn were administered an equivalent volume of control vehicle. On Day 26 of gestation, no significant enhancement of lung maturation, as judged from the pressure volume relationship, was found to result from prolactin administration. These results suggest that prolactin does not initiate the secretion of surface active material into the alveolar lumen of the fetal lung in sufficient amounts to induce physiologic maturation of the rabbit fetal lung.
G R Van Petten, and
R Bridges
January 1978,
American journal of obstetrics and gynecology,
G R Van Petten, and
R Bridges
August 1980,
The Journal of clinical investigation,
G R Van Petten, and
R Bridges
July 1982,
Seminars in perinatology,
G R Van Petten, and
R Bridges
September 1981,
Pediatric research,
G R Van Petten, and
R Bridges
July 2009,
Pediatric surgery international,
G R Van Petten, and
R Bridges
March 1976,
American journal of obstetrics and gynecology,
G R Van Petten, and
R Bridges
January 1978,
Obstetrics and gynecology,
G R Van Petten, and
R Bridges
January 1992,
The Anatomical record,
G R Van Petten, and
R Bridges
October 1971,
Pediatrics,
G R Van Petten, and
R Bridges
July 1981,
Developmental biology,
