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A study of relative bioavailability of two digoxin formulations was carried out on 28 healthy volunteer human subjects of both sexes. A commercial digoxin in tablet form was compared with a new commercial formulation which contains a solution of digoxin in soft gelatin capsules. The parameters investigated were: plasma levels, area under the plasma level-time curve, daily urinary excretion of digoxin and a series of polycardiographic measurements, all the parameters being evaluated in a steady-state condition (14 days of treatment). All the parameters investigated demonstrated better bioavailability in the capsules than in the tablets, the average improvement being 26.1%. The better bioavailability of digoxin capsules also resulted in more rapid and wider variations in the polycardiographic parameters.
V Alvisi, and
C Longhini, and
B Bagni, and
F Portaluppi, and
M Ruina, and
C Fersini
January 1976,
Bollettino della Societa italiana di cardiologia,
V Alvisi, and
C Longhini, and
B Bagni, and
F Portaluppi, and
M Ruina, and
C Fersini
December 1975,
Clinical pharmacology and therapeutics,
V Alvisi, and
C Longhini, and
B Bagni, and
F Portaluppi, and
M Ruina, and
C Fersini
January 1979,
British journal of clinical pharmacology,
V Alvisi, and
C Longhini, and
B Bagni, and
F Portaluppi, and
M Ruina, and
C Fersini
March 1977,
Clinical pharmacology and therapeutics,
V Alvisi, and
C Longhini, and
B Bagni, and
F Portaluppi, and
M Ruina, and
C Fersini
February 1978,
Bollettino chimico farmaceutico,
V Alvisi, and
C Longhini, and
B Bagni, and
F Portaluppi, and
M Ruina, and
C Fersini
October 1974,
Bollettino della Societa italiana di biologia sperimentale,
V Alvisi, and
C Longhini, and
B Bagni, and
F Portaluppi, and
M Ruina, and
C Fersini
March 1976,
Journal of pharmaceutical sciences,
V Alvisi, and
C Longhini, and
B Bagni, and
F Portaluppi, and
M Ruina, and
C Fersini
July 1978,
International journal of clinical pharmacology and biopharmacy,
V Alvisi, and
C Longhini, and
B Bagni, and
F Portaluppi, and
M Ruina, and
C Fersini
September 1977,
The Journal of pharmacy and pharmacology,
V Alvisi, and
C Longhini, and
B Bagni, and
F Portaluppi, and
M Ruina, and
C Fersini
December 1977,
European journal of clinical pharmacology,
