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The pharmacokinetic behaviour of N-acetyl-p-aminophenol (paracetamol) after single dose applications of 500 mg and 1000 mg dosages in the form of liquids, tablets and suppositories was compared. The estimation of the pharmacokinetic constants by a simultaneous curve fitting with a direct search procedure, based on an open two-compartment model, showed for the liquid as well as for the tablet formulation a good conformable and dosage proportional behaviour of the relative bioavailability. In opposite to the oral application, the suppositories had a significantly reduced invasion kinetics with a comparable elimination kinetics characterized by a lowering of Cmax and an increase of Tmax-values with comparable AUCs. The calculation of collapse-coefficients showed, with the exception of one suppository formulation, for all administrations a pharmacokinetic behaviour deviating from an open one-compartment model. The clinical consequences resulting from the pharmacokinetic behaviour of the different galenic formulations and routes of administrations are discussed.
R Liedtke, and
G Berner, and
W Haase, and
W Nicolai, and
R Staab, and
H H Wagener
December 1992,
Therapeutic drug monitoring,
R Liedtke, and
G Berner, and
W Haase, and
W Nicolai, and
R Staab, and
H H Wagener
April 1998,
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences,
R Liedtke, and
G Berner, and
W Haase, and
W Nicolai, and
R Staab, and
H H Wagener
October 2015,
Environment international,
R Liedtke, and
G Berner, and
W Haase, and
W Nicolai, and
R Staab, and
H H Wagener
January 1979,
Arzneimittel-Forschung,
R Liedtke, and
G Berner, and
W Haase, and
W Nicolai, and
R Staab, and
H H Wagener
November 1980,
European journal of clinical pharmacology,
R Liedtke, and
G Berner, and
W Haase, and
W Nicolai, and
R Staab, and
H H Wagener
September 1999,
Acta anaesthesiologica Scandinavica,
R Liedtke, and
G Berner, and
W Haase, and
W Nicolai, and
R Staab, and
H H Wagener
May 1982,
Masui. The Japanese journal of anesthesiology,
R Liedtke, and
G Berner, and
W Haase, and
W Nicolai, and
R Staab, and
H H Wagener
September 2018,
BMC veterinary research,
R Liedtke, and
G Berner, and
W Haase, and
W Nicolai, and
R Staab, and
H H Wagener
July 1991,
Journal of pharmaceutical sciences,
R Liedtke, and
G Berner, and
W Haase, and
W Nicolai, and
R Staab, and
H H Wagener
October 1996,
International journal of clinical pharmacology and therapeutics,
