-transparent.png){kind=logo}
Chromatographic characteristics of urinary metabolites of theophylline were studied by two-dimensional thin-layer chromatography, high-performance liquid chromatography and gas chromatography--mass spectrometry. Quantitative date for the urinary metabolites of theophylline in asthmatic children are given. It was shown that 1,3-dimethyluric acid is the predominant excretory product. In addition, smaller amounts of 1-methyluric acid, 3-methylxanthine and unchanged theophylline were found. Excretory patterns after theophylline ingestion before and during the administration of allopurinol in asthma patients and in rats suggest the existence of three metabolic pathways of theophylline. The administration of this drug to a patient with xanthine oxidase of theophylline. The administration of this drug to a patient with xanthine oxidase deficiency resulted in the excretion of 1-methyluric acid in addition to 1,3-dimethyluric acid, 3-methylxanthine, 1-methylxanthine and unchanged theophylline. It was concluded that in man the oxidation of theophylline is not catalysed by xanthine oxidase.
A H van Gennip, and
J Grift, and
E J van Bree-Blom, and
D Ketting, and
S K Wadman
March 1972,
Biochimica et biophysica acta,
A H van Gennip, and
J Grift, and
E J van Bree-Blom, and
D Ketting, and
S K Wadman
May 1980,
Chemico-biological interactions,
A H van Gennip, and
J Grift, and
E J van Bree-Blom, and
D Ketting, and
S K Wadman
June 1974,
Experientia,
A H van Gennip, and
J Grift, and
E J van Bree-Blom, and
D Ketting, and
S K Wadman
July 1978,
Cancer research,
A H van Gennip, and
J Grift, and
E J van Bree-Blom, and
D Ketting, and
S K Wadman
August 2005,
Clinical chemistry,
A H van Gennip, and
J Grift, and
E J van Bree-Blom, and
D Ketting, and
S K Wadman
February 1966,
Nature,
A H van Gennip, and
J Grift, and
E J van Bree-Blom, and
D Ketting, and
S K Wadman
March 1969,
Life sciences,
A H van Gennip, and
J Grift, and
E J van Bree-Blom, and
D Ketting, and
S K Wadman
May 1974,
Cancer research,
A H van Gennip, and
J Grift, and
E J van Bree-Blom, and
D Ketting, and
S K Wadman
January 1970,
Acta pharmacologica et toxicologica,
A H van Gennip, and
J Grift, and
E J van Bree-Blom, and
D Ketting, and
S K Wadman
October 1978,
Biochimica et biophysica acta,
