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Acute diabetes with ketosis was induced in rats by intraperitoneal streptozotocin and also a milder form of diabetes without ketosis by injecting less of the drug. The acutely diabetic rats were killed 72h after injection and the others after either 2 or 13 weeks. Free and lipid myo-inositol was then measured in various tissues and body fluids by g.l.c. of the trimethylsilyl ether. Serum inositol was increased in the acutely diabetic group, whereas liver inositol was decreased. Brain and kidney inositol concentrations were increased in the mildly diabetic animals at 13 weeks and there was a progressive decrease in sciatic-nerve inositol. Lipid inositol of sciatic nerve was decreased in the acutely diabetic group only. Brain lipid inositol concentration was decreased in mild diabetes at 13 weeks. Possible implications of these findings in relation to diabetic neuropathy was discussed.
K P Palmano, and
P H Whiting, and
J N Hawthorne
December 1986,
Diabetologia,
K P Palmano, and
P H Whiting, and
J N Hawthorne
December 1990,
Proceedings of the National Academy of Sciences of the United States of America,
K P Palmano, and
P H Whiting, and
J N Hawthorne
June 1980,
Archives of biochemistry and biophysics,
K P Palmano, and
P H Whiting, and
J N Hawthorne
August 1989,
Mayo Clinic proceedings,
K P Palmano, and
P H Whiting, and
J N Hawthorne
October 1992,
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies,
K P Palmano, and
P H Whiting, and
J N Hawthorne
August 1974,
Biochimica et biophysica acta,
K P Palmano, and
P H Whiting, and
J N Hawthorne
August 1983,
Biochimica et biophysica acta,
K P Palmano, and
P H Whiting, and
J N Hawthorne
May 1968,
Biochimica et biophysica acta,
K P Palmano, and
P H Whiting, and
J N Hawthorne
February 1981,
Journal of neurochemistry,
K P Palmano, and
P H Whiting, and
J N Hawthorne
June 1963,
Biochimica et biophysica acta,
