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1. Dose-response relationships to K+ were determined in isolated strips of rabbit aorta. 2. K+ contractures were induced by 30 mM K+ in paired strips from individual animals. The effects of hydralazine and hydralazine acetone hydrazone (hydralazine acetonide) on these contractures were studied. 3. Hydralazine and hydralazine acetonide both produced dose-dependent decreases of K+-induced tone. Threshold concentrations for hydralazine were 11.89 +/- 4.5 X 10(-5) M (mean +/- s.d.) and for hydralazine actonide 9.7 +/- 4.6 X 10(-5) M (0.5 less than P less than 0.4). 4. The magnitude of the effect of hydralazine acetonide was greater than that of hydralazine at all concentrations above threshold, as reflected in a significant difference (P less than 0.05) in the slopes of dose-response curves to the two treatments. The vasodilator effects of hydralazine and the acetonide were terminated by washout of the bath. 5. The differences in effect were not due to instability of hydralazine under in vitro conditions. 6. It is concluded that hydralazine acetonide has intrinsic activity on vascular smooth muscle which differs significantly from that of the parent compound and that this may contribute to the hypotensive effects which follow administration of the parent compound.
K Barron, and
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A J McLean, and
J L McNay, and
P Du Souich
August 1981,
British journal of pharmacology,
K Barron, and
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July 1985,
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K Barron, and
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P Du Souich
May 1977,
British journal of pharmacology,
K Barron, and
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A J McLean, and
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P Du Souich
March 1978,
British journal of pharmacology,
K Barron, and
O Carrier, and
K D Haegele, and
A J McLean, and
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November 1981,
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January 1996,
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K Barron, and
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August 1983,
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K Barron, and
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A J McLean, and
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September 1984,
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K Barron, and
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February 1990,
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